IOCAS-IR  > 海洋生物技术研发中心
Exploring the Antibacterial and Antifungal Potential of Jellyfish-Associated Marine Fungi by Cultivation-Dependent Approaches
Yue, Yang1,2; Yu, Huahua1; Li, Rongfeng1; Xing, Ronge1; Liu, Song1; Li, Pengcheng1
2015-12-04
发表期刊PLOS ONE
卷号10期号:12页码:0144394
文章类型Article
摘要Fungi isolated from marine invertebrates are of considerable importance as new promising sources of unique secondary metabolites with significant biomedical potential. However, the cultivable fungal community harbored in jellyfish was less investigated. In this work, we seek to recover symbiotic fungi from different tissues of jellyfish Nemopilema nomurai. A total of seven morphotypes were isolated, which were assigned into four genera (Aspergillus, Cladosporium, Purpureocillium, and Tilletiopsis) from two phyla (Ascomycota and Basidiomycota) by comparing the rDNA-ITS sequences with the reference sequences in GenBank. The most fungi were found in the inner tissues of subumbrella. Two of the cultivation- independent procedures, changing media type and co-cultivation, were employed to maximize the complexity of metabolites. Thus, thirteen EtOAc gum were obtained and fingerprinted by High Performance Liquid Chromatography (HPLC) equipped with a photodiode array (PDA) detector. Antibacterial and antifungal activities of these complex mixtures were tested against a panel of bacterial and fungal pathogens. The antimicrobial results showed that all of the 13 EtOAc extracts displayed different levels of antibacterial activity, three of which exhibited strong to significant antibacterial activity to the bacterial pathogens Staphylococcus aureus and Salmonella entrica. Antifungal activity indicated that the EtOAc extracts from pure culture of Aspergillus versicolor and co-culture of A. versicolor and Tilletiopsis sp. in rice media were promising for searching new compounds, with the maximal mycelial growth inhibition of 82.32% +/- 0.61% for Rhizoctonia solani and 48.41% +/- 11.02% for Botrytis cinerea at 200 mu g/ml, respectively. This study is the first report on the antibacterial and antifungal activity of jellyfish-associated fungi and allows the first sight into cultivable fungal community residing in jellyfish. Induced metabolites by cultivation-dependent approaches provides a new reservoir for drug discovery from jellyfish-derived fungi.
DOI10.1371/journal.pone.0144394
收录类别SCI
语种英语
WOS记录号WOS:000366143800085
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/86606
专题海洋生物技术研发中心
实验海洋生物学重点实验室
海洋环境工程技术研究发展中心
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Yue, Yang,Yu, Huahua,Li, Rongfeng,et al. Exploring the Antibacterial and Antifungal Potential of Jellyfish-Associated Marine Fungi by Cultivation-Dependent Approaches[J]. PLOS ONE,2015,10(12):0144394.
APA Yue, Yang,Yu, Huahua,Li, Rongfeng,Xing, Ronge,Liu, Song,&Li, Pengcheng.(2015).Exploring the Antibacterial and Antifungal Potential of Jellyfish-Associated Marine Fungi by Cultivation-Dependent Approaches.PLOS ONE,10(12),0144394.
MLA Yue, Yang,et al."Exploring the Antibacterial and Antifungal Potential of Jellyfish-Associated Marine Fungi by Cultivation-Dependent Approaches".PLOS ONE 10.12(2015):0144394.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Exploring the Antiba(2226KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yue, Yang]的文章
[Yu, Huahua]的文章
[Li, Rongfeng]的文章
百度学术
百度学术中相似的文章
[Yue, Yang]的文章
[Yu, Huahua]的文章
[Li, Rongfeng]的文章
必应学术
必应学术中相似的文章
[Yue, Yang]的文章
[Yu, Huahua]的文章
[Li, Rongfeng]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Exploring the Antibacterial and Antifungal Potential of Jellyfish-Associated Marine Fungi by Cultivation-Dependent Approaches.PDF
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。