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Characterization of a Newly Isolated Marine Fungus Aspergillus dimorphicus for Optimized Production of the Anti-Tumor Agent Wentilactones
Xu, Rui1,2; Xu, Gang-Ming1; Li, Xiao-Ming1; Li, Chun-Shun1; Wang, Bin-Gui1
2015-11-01
发表期刊MARINE DRUGS
卷号13期号:11页码:7040-7054
文章类型Article
摘要The potential anti-tumor agent wentilactones were produced by a newly isolated marine fungus Aspergillus dimorphicus. This fungus was derived from deep-sea sediment and identified by polyphasic approach, combining phenotypic, molecular, and extrolite profiles. However, wentilactone production was detected only under static cultures with very low yields. In order to improve wentilactone production, culture conditions were optimized using the response surface methodology. Under the optimal static fermentation conditions, the experimental values were closely consistent with the prediction model. The yields of wentilactone A and B were increased about 11-fold to 13.4 and 6.5 mg/L, respectively. The result was further verified by fermentation scale-up for wentilactone production. Moreover, some small-molecule elicitors were found to have capacity of stimulating wentilactone production. To our knowledge, this is first report of optimized production of tetranorlabdane diterpenoids by a deep-sea derived marine fungus. The present study might be valuable for efficient production of wentilactones and fundamental investigation of the anti-tumor mechanism of norditerpenoids.
关键词Aspergillus Dimorphicus Anti-tumor Agent Wentilactones Optimization
DOI10.3390/md13117040
收录类别SCI
语种英语
WOS记录号WOS:000365645400025
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/86533
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Coll Earth Sci, Beijing 100049, Peoples R China
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Xu, Rui,Xu, Gang-Ming,Li, Xiao-Ming,et al. Characterization of a Newly Isolated Marine Fungus Aspergillus dimorphicus for Optimized Production of the Anti-Tumor Agent Wentilactones[J]. MARINE DRUGS,2015,13(11):7040-7054.
APA Xu, Rui,Xu, Gang-Ming,Li, Xiao-Ming,Li, Chun-Shun,&Wang, Bin-Gui.(2015).Characterization of a Newly Isolated Marine Fungus Aspergillus dimorphicus for Optimized Production of the Anti-Tumor Agent Wentilactones.MARINE DRUGS,13(11),7040-7054.
MLA Xu, Rui,et al."Characterization of a Newly Isolated Marine Fungus Aspergillus dimorphicus for Optimized Production of the Anti-Tumor Agent Wentilactones".MARINE DRUGS 13.11(2015):7040-7054.
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