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Characterization of a Newly Isolated Marine Fungus Aspergillus dimorphicus for Optimized Production of the Anti-Tumor Agent Wentilactones
Xu, Rui1,2; Xu, Gang-Ming1; Li, Xiao-Ming1; Li, Chun-Shun1; Wang, Bin-Gui1
2015-11-01
Source PublicationMARINE DRUGS
Volume13Issue:11Pages:7040-7054
SubtypeArticle
AbstractThe potential anti-tumor agent wentilactones were produced by a newly isolated marine fungus Aspergillus dimorphicus. This fungus was derived from deep-sea sediment and identified by polyphasic approach, combining phenotypic, molecular, and extrolite profiles. However, wentilactone production was detected only under static cultures with very low yields. In order to improve wentilactone production, culture conditions were optimized using the response surface methodology. Under the optimal static fermentation conditions, the experimental values were closely consistent with the prediction model. The yields of wentilactone A and B were increased about 11-fold to 13.4 and 6.5 mg/L, respectively. The result was further verified by fermentation scale-up for wentilactone production. Moreover, some small-molecule elicitors were found to have capacity of stimulating wentilactone production. To our knowledge, this is first report of optimized production of tetranorlabdane diterpenoids by a deep-sea derived marine fungus. The present study might be valuable for efficient production of wentilactones and fundamental investigation of the anti-tumor mechanism of norditerpenoids.
KeywordAspergillus Dimorphicus Anti-tumor Agent Wentilactones Optimization
DOI10.3390/md13117040
Indexed BySCI
Language英语
WOS IDWOS:000365645400025
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/86533
Collection实验海洋生物学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Coll Earth Sci, Beijing 100049, Peoples R China
First Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Xu, Rui,Xu, Gang-Ming,Li, Xiao-Ming,et al. Characterization of a Newly Isolated Marine Fungus Aspergillus dimorphicus for Optimized Production of the Anti-Tumor Agent Wentilactones[J]. MARINE DRUGS,2015,13(11):7040-7054.
APA Xu, Rui,Xu, Gang-Ming,Li, Xiao-Ming,Li, Chun-Shun,&Wang, Bin-Gui.(2015).Characterization of a Newly Isolated Marine Fungus Aspergillus dimorphicus for Optimized Production of the Anti-Tumor Agent Wentilactones.MARINE DRUGS,13(11),7040-7054.
MLA Xu, Rui,et al."Characterization of a Newly Isolated Marine Fungus Aspergillus dimorphicus for Optimized Production of the Anti-Tumor Agent Wentilactones".MARINE DRUGS 13.11(2015):7040-7054.
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