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A short-type peptidoglycan recognition protein from tongue sole (Cynoglossus semilaevis) promotes phagocytosis and defense against bacterial infection
Sun, Qing-lei1,2,3; Sun, Li1,2
2015-11-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
Volume47Issue:1Pages:313-320
SubtypeArticle
AbstractPeptidoglycan recognition proteins (PGRPs) are members of the innate immune system that interact with bacteria by binding to bacterial peptidoglycan. In this study, we examined the expression and function of a short type of PGRP, CsPGRP-SC2, from tongue sole (Cynoglossus semilaevis). CsPGRP-SC2 contains 164 amino acid residues and shares 54.5%-65.3% overall sequence identities with other teleost PGRPs. CsPGRP-SC2 possesses an amidase domain with a conserved zinc binding site. CsPGRP-SC2 expression occurred in multiple tissues and was upregulated by bacterial and viral infection. Purified recombinant C5PGRP-SC2 (rC5PGRP-SC2) was able to bind and agglutinate Gram-positive bacteria in a Zn2+-dependent manner. rCsPGRP-SC2 enhanced the uptake of the bound bacteria by host phagocytes and reduced bacterial dissemination and colonization in host tissues. These results indicate that CsPGRP-SC2 is an innate immune factor that participates in host defense against bacterial infection. (C) 2015 Elsevier Ltd. All rights reserved.
KeywordPeptidoglycan Recognition Protein Cynoglossus Semilaevis Agglutination Phagocytosis Antibacterial Effects
DOI10.1016/j.fsi.2015.09.021
Indexed BySCI
Language英语
WOS IDWOS:000365053300036
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/82325
Collection实验海洋生物学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
First Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Sun, Qing-lei,Sun, Li. A short-type peptidoglycan recognition protein from tongue sole (Cynoglossus semilaevis) promotes phagocytosis and defense against bacterial infection[J]. FISH & SHELLFISH IMMUNOLOGY,2015,47(1):313-320.
APA Sun, Qing-lei,&Sun, Li.(2015).A short-type peptidoglycan recognition protein from tongue sole (Cynoglossus semilaevis) promotes phagocytosis and defense against bacterial infection.FISH & SHELLFISH IMMUNOLOGY,47(1),313-320.
MLA Sun, Qing-lei,et al."A short-type peptidoglycan recognition protein from tongue sole (Cynoglossus semilaevis) promotes phagocytosis and defense against bacterial infection".FISH & SHELLFISH IMMUNOLOGY 47.1(2015):313-320.
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