A short-type peptidoglycan recognition protein from tongue sole (Cynoglossus semilaevis) promotes phagocytosis and defense against bacterial infection

doi:10.1016/j.fsi.2015.09.021

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	A short-type peptidoglycan recognition protein from tongue sole (Cynoglossus semilaevis) promotes phagocytosis and defense against bacterial infection
	Sun, Qing-lei1,2,3 ; Sun, Li 1,2
	2015-11-01
发表期刊	FISH & SHELLFISH IMMUNOLOGY
卷号	47 期号:1 页码:313-320
文章类型	Article
摘要	Peptidoglycan recognition proteins (PGRPs) are members of the innate immune system that interact with bacteria by binding to bacterial peptidoglycan. In this study, we examined the expression and function of a short type of PGRP, CsPGRP-SC2, from tongue sole (Cynoglossus semilaevis). CsPGRP-SC2 contains 164 amino acid residues and shares 54.5%-65.3% overall sequence identities with other teleost PGRPs. CsPGRP-SC2 possesses an amidase domain with a conserved zinc binding site. CsPGRP-SC2 expression occurred in multiple tissues and was upregulated by bacterial and viral infection. Purified recombinant C5PGRP-SC2 (rC5PGRP-SC2) was able to bind and agglutinate Gram-positive bacteria in a Zn2+-dependent manner. rCsPGRP-SC2 enhanced the uptake of the bound bacteria by host phagocytes and reduced bacterial dissemination and colonization in host tissues. These results indicate that CsPGRP-SC2 is an innate immune factor that participates in host defense against bacterial infection. (C) 2015 Elsevier Ltd. All rights reserved.
关键词	Peptidoglycan Recognition Protein Cynoglossus Semilaevis Agglutination Phagocytosis Antibacterial Effects
DOI	10.1016/j.fsi.2015.09.021
收录类别	SCI
语种	英语
WOS记录号	WOS:000365053300036
引用统计	被引频次：21[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/82325
专题	实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位	实验海洋生物学重点实验室
推荐引用方式 GB/T 7714	Sun, Qing-lei,Sun, Li. A short-type peptidoglycan recognition protein from tongue sole (Cynoglossus semilaevis) promotes phagocytosis and defense against bacterial infection[J]. FISH & SHELLFISH IMMUNOLOGY,2015,47(1):313-320.
APA	Sun, Qing-lei,&Sun, Li.(2015).A short-type peptidoglycan recognition protein from tongue sole (Cynoglossus semilaevis) promotes phagocytosis and defense against bacterial infection.FISH & SHELLFISH IMMUNOLOGY,47(1),313-320.
MLA	Sun, Qing-lei,et al."A short-type peptidoglycan recognition protein from tongue sole (Cynoglossus semilaevis) promotes phagocytosis and defense against bacterial infection".FISH & SHELLFISH IMMUNOLOGY 47.1(2015):313-320.

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文件名称/大小	文献类型	版本类型	开放类型	使用许可
A short-type peptido（1828KB）	期刊论文	出版稿	限制开放	CC BY-NC-SA	浏览