| Low molecular weight fucoidan ameliorates diabetic nephropathy via inhibiting epithelial-mesenchymal transition and fibrotic processes | |
| Chen, Jihui1,2,3; Cui, Wentong4; Zhang, Quanbin5; Jia, Yingli1,2; Sun, Yi1,2; Weng, Lin1,2; Luo, Dali4; Zhou, Hong1,2; Yang, Baoxue1,2 | |
| 2015 | |
| 发表期刊 | AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
 |
| 卷号 | 7期号:9页码:1553-1563 |
| 文章类型 | Article |
| 摘要 | Diabetic nephropathy (DN) is one of the most serious microvascular complications of diabetes and may lead to end-stage renal disease (ESRD) and chronic renal failure. The aim of this study was to determine whether low-molecular-weight fucoidan (LMWF) can reduce harmful transforming growth factor-beta (TGF-beta)-mediated renal fibrosis in DN using in vitro and in vivo experimental models. The experimental results showed that LMWF significantly reversed TGF-beta 1-induced epithelial-mesenchymal transition and dose-dependently inhibited accumulation of extracellular matrix proteins, including connective tissue growth factor and fibronectin. It was found that LMWF significantly reduced blood urea nitrogen and blood creatinine in both type 1 and type 2 diabetic rat models. H&E, PAS and Masson's trichrome staining of kidney tissue showed LMWF significantly reduced renal interstitial fibrosis. Treatment with LMWF significantly increased E-cadherin expression and reduced alpha-SMA, CTGF and fibronectin expression in both type 1 and type 2 diabetic models. LMWF also decreased the phosphorylation of Akt, ERK1/2, p38 and Smad3 in vitro and in vivo. These data suggest that LMWF may protect kidney from dysfunction and fibrogenesis by inhibiting TGF-beta pathway and have the potential benefit to slow down the progression of DN. |
| 关键词 | Fucoidan Diabetic Nephropathy Epithelialto-mesenchymal Transition Transforming Growth Factor-beta 1 Extracellular Matrix Tubulointerstitial Fibrosis |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000364771500007 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/82294 |
| 专题 | 海洋生物技术研发中心 |
| 作者单位 | 1.Peking Univ, Sch Basic Med Sci, Minist Educ, State Key Lab Nat & Biomimet Drugs,Key Lab Mol Ca, Beijing 100191, Peoples R China 2.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100191, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Med, Dept Pharm, Xin Hua Hosp, Shanghai 200092, Peoples R China 4.Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China 5.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Jihui,Cui, Wentong,Zhang, Quanbin,et al. Low molecular weight fucoidan ameliorates diabetic nephropathy via inhibiting epithelial-mesenchymal transition and fibrotic processes[J]. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,2015,7(9):1553-1563. |
| APA | Chen, Jihui.,Cui, Wentong.,Zhang, Quanbin.,Jia, Yingli.,Sun, Yi.,...&Yang, Baoxue.(2015).Low molecular weight fucoidan ameliorates diabetic nephropathy via inhibiting epithelial-mesenchymal transition and fibrotic processes.AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,7(9),1553-1563. |
| MLA | Chen, Jihui,et al."Low molecular weight fucoidan ameliorates diabetic nephropathy via inhibiting epithelial-mesenchymal transition and fibrotic processes".AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 7.9(2015):1553-1563. |
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