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Low molecular weight fucoidan ameliorates diabetic nephropathy via inhibiting epithelial-mesenchymal transition and fibrotic processes
Chen, Jihui1,2,3; Cui, Wentong4; Zhang, Quanbin5; Jia, Yingli1,2; Sun, Yi1,2; Weng, Lin1,2; Luo, Dali4; Zhou, Hong1,2; Yang, Baoxue1,2
2015
发表期刊AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
卷号7期号:9页码:1553-1563
文章类型Article
摘要Diabetic nephropathy (DN) is one of the most serious microvascular complications of diabetes and may lead to end-stage renal disease (ESRD) and chronic renal failure. The aim of this study was to determine whether low-molecular-weight fucoidan (LMWF) can reduce harmful transforming growth factor-beta (TGF-beta)-mediated renal fibrosis in DN using in vitro and in vivo experimental models. The experimental results showed that LMWF significantly reversed TGF-beta 1-induced epithelial-mesenchymal transition and dose-dependently inhibited accumulation of extracellular matrix proteins, including connective tissue growth factor and fibronectin. It was found that LMWF significantly reduced blood urea nitrogen and blood creatinine in both type 1 and type 2 diabetic rat models. H&E, PAS and Masson's trichrome staining of kidney tissue showed LMWF significantly reduced renal interstitial fibrosis. Treatment with LMWF significantly increased E-cadherin expression and reduced alpha-SMA, CTGF and fibronectin expression in both type 1 and type 2 diabetic models. LMWF also decreased the phosphorylation of Akt, ERK1/2, p38 and Smad3 in vitro and in vivo. These data suggest that LMWF may protect kidney from dysfunction and fibrogenesis by inhibiting TGF-beta pathway and have the potential benefit to slow down the progression of DN.
关键词Fucoidan Diabetic Nephropathy Epithelialto-mesenchymal Transition Transforming Growth Factor-beta 1 Extracellular Matrix Tubulointerstitial Fibrosis
收录类别SCI
语种英语
WOS记录号WOS:000364771500007
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/82294
专题海洋生物技术研发中心
作者单位1.Peking Univ, Sch Basic Med Sci, Minist Educ, State Key Lab Nat & Biomimet Drugs,Key Lab Mol Ca, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100191, Peoples R China
3.Shanghai Jiao Tong Univ, Sch Med, Dept Pharm, Xin Hua Hosp, Shanghai 200092, Peoples R China
4.Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China
5.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
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Chen, Jihui,Cui, Wentong,Zhang, Quanbin,et al. Low molecular weight fucoidan ameliorates diabetic nephropathy via inhibiting epithelial-mesenchymal transition and fibrotic processes[J]. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,2015,7(9):1553-1563.
APA Chen, Jihui.,Cui, Wentong.,Zhang, Quanbin.,Jia, Yingli.,Sun, Yi.,...&Yang, Baoxue.(2015).Low molecular weight fucoidan ameliorates diabetic nephropathy via inhibiting epithelial-mesenchymal transition and fibrotic processes.AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,7(9),1553-1563.
MLA Chen, Jihui,et al."Low molecular weight fucoidan ameliorates diabetic nephropathy via inhibiting epithelial-mesenchymal transition and fibrotic processes".AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 7.9(2015):1553-1563.
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