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Synthesis and biological evaluation of novel fluorinated anticancer agents incorporating the indolin-2-one moiety
Wang, Shuai-Yu; Wang, Li-Jun; Jiang, Bo; Wu, Ning; Li, Xiang-Qian; Luo, Jiao; Wang, Bao-Cheng; Zhang, Ren-Shuai; Xu, Qi; Shi, Da-Yong
2015
发表期刊RSC Advances
卷号5期号:111页码:91795-91801
文章类型Article
摘要A series of novel fluorinated anticancer agents containing the indolin-2-one moiety were designed, synthesized and evaluated for their anticancer activities in vitro. Among them, compounds 6, 7, 9, 12 and 13 showed potent activities against the tested human cancer cell lines. Notably, compound 6 showed significant activities against A549, Bel7402, HepG2, HCT116 and HeLa cancer cell lines, which were comparable to those of sunitinib. Further study on its mechanisms demonstrated that compound 6 can be used as a potential anticancer agent for inhibiting proliferation and inducing apoptosis of HepG2 cells, along with inhibiting angiogenesis of HUVECs.
DOI10.1039/c5ra19617e
收录类别SCI
语种英语
WOS记录号WOS:000364057000084
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/82292
专题海洋生物技术研发中心
作者单位Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Beijing 100864, Peoples R China
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Wang, Shuai-Yu,Wang, Li-Jun,Jiang, Bo,et al. Synthesis and biological evaluation of novel fluorinated anticancer agents incorporating the indolin-2-one moiety[J]. RSC Advances,2015,5(111):91795-91801.
APA Wang, Shuai-Yu.,Wang, Li-Jun.,Jiang, Bo.,Wu, Ning.,Li, Xiang-Qian.,...&Shi, Da-Yong.(2015).Synthesis and biological evaluation of novel fluorinated anticancer agents incorporating the indolin-2-one moiety.RSC Advances,5(111),91795-91801.
MLA Wang, Shuai-Yu,et al."Synthesis and biological evaluation of novel fluorinated anticancer agents incorporating the indolin-2-one moiety".RSC Advances 5.111(2015):91795-91801.
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