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Synthesis and biological evaluation of novel fluorinated anticancer agents incorporating the indolin-2-one moiety
Wang, Shuai-Yu; Wang, Li-Jun; Jiang, Bo; Wu, Ning; Li, Xiang-Qian; Luo, Jiao; Wang, Bao-Cheng; Zhang, Ren-Shuai; Xu, Qi; Shi, Da-Yong
2015
Source PublicationRSC Advances
Volume5Issue:111Pages:91795-91801
SubtypeArticle
AbstractA series of novel fluorinated anticancer agents containing the indolin-2-one moiety were designed, synthesized and evaluated for their anticancer activities in vitro. Among them, compounds 6, 7, 9, 12 and 13 showed potent activities against the tested human cancer cell lines. Notably, compound 6 showed significant activities against A549, Bel7402, HepG2, HCT116 and HeLa cancer cell lines, which were comparable to those of sunitinib. Further study on its mechanisms demonstrated that compound 6 can be used as a potential anticancer agent for inhibiting proliferation and inducing apoptosis of HepG2 cells, along with inhibiting angiogenesis of HUVECs.
DOI10.1039/c5ra19617e
Indexed BySCI
Language英语
WOS IDWOS:000364057000084
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/82292
Collection海洋生物技术研发中心
AffiliationChinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Beijing 100864, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Wang, Shuai-Yu,Wang, Li-Jun,Jiang, Bo,et al. Synthesis and biological evaluation of novel fluorinated anticancer agents incorporating the indolin-2-one moiety[J]. RSC Advances,2015,5(111):91795-91801.
APA Wang, Shuai-Yu.,Wang, Li-Jun.,Jiang, Bo.,Wu, Ning.,Li, Xiang-Qian.,...&Shi, Da-Yong.(2015).Synthesis and biological evaluation of novel fluorinated anticancer agents incorporating the indolin-2-one moiety.RSC Advances,5(111),91795-91801.
MLA Wang, Shuai-Yu,et al."Synthesis and biological evaluation of novel fluorinated anticancer agents incorporating the indolin-2-one moiety".RSC Advances 5.111(2015):91795-91801.
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