IOCAS-IR  > 海洋生物技术研发中心
A new method to evaluate the effects of bacterial dosage, infection route and Vibrio strain in experimental challenges of Litopenaeus vannamei, based on the Cox proportional hazard model
Xia, Qing1,2; Wang, Baojie1; Liu, Mei1; Jiang, Keyong1; Wang, Lei1
2015-10-01
发表期刊FISH & SHELLFISH IMMUNOLOGY
卷号46期号:2页码:686-692
文章类型Article
摘要In the shrimp challenge test the Vibrio dosage, infection route, and strain are considered as risk factors that result in mortality. Assessment of Vibrio/shrimp interactions, and disease dynamics following infection by Vibrio, are useful techniques needed for detailed studies on the control of risk factors. In this paper we used an application of the Cox proportional hazard model to assess relative survival probability, estimate mortality risk, and construct a prognostic model to assess predictions of estimated time to death. Results indicate that infection route was the most important prognostic factor contributing to mortality in the challenge test (beta = 3.698, P < 0.000). The shrimp infection rate following injection was found to be 40.4 times greater than that following immersion (hazard ratio (HR) = 40.4; p = 0.000). Our results also indicated that the HR resulting in shrimp mortality following a high dose of 10(8) cfu/shrimp was significantly greater (HR = 5.9, P < 0.000), than that following a baseline dosage of 10(7) cfu/shrimp. Strain Vh was found to be more virulent than Strain Vp (HR = 4.8; P < 0.000). The prognostic index also indicated that the infection route is the most important prognostic factor contributing to mortality in the challenge test. (C) 2015 Elsevier Ltd. All rights reserved.
关键词Vibrio Experimental Challenges Cox Proportional Hazards (Ph) Model Mortality Prognostic Index Litopenaeus Vannamei
DOI10.1016/j.fsi.2015.07.009
收录类别SCI
语种英语
WOS记录号WOS:000363071200058
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/73941
专题海洋生物技术研发中心
作者单位1.Chinese Acad Sci, Inst Oceanol, Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao, Shandong, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714
Xia, Qing,Wang, Baojie,Liu, Mei,et al. A new method to evaluate the effects of bacterial dosage, infection route and Vibrio strain in experimental challenges of Litopenaeus vannamei, based on the Cox proportional hazard model[J]. FISH & SHELLFISH IMMUNOLOGY,2015,46(2):686-692.
APA Xia, Qing,Wang, Baojie,Liu, Mei,Jiang, Keyong,&Wang, Lei.(2015).A new method to evaluate the effects of bacterial dosage, infection route and Vibrio strain in experimental challenges of Litopenaeus vannamei, based on the Cox proportional hazard model.FISH & SHELLFISH IMMUNOLOGY,46(2),686-692.
MLA Xia, Qing,et al."A new method to evaluate the effects of bacterial dosage, infection route and Vibrio strain in experimental challenges of Litopenaeus vannamei, based on the Cox proportional hazard model".FISH & SHELLFISH IMMUNOLOGY 46.2(2015):686-692.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
A new method to eval(568KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Xia, Qing]的文章
[Wang, Baojie]的文章
[Liu, Mei]的文章
百度学术
百度学术中相似的文章
[Xia, Qing]的文章
[Wang, Baojie]的文章
[Liu, Mei]的文章
必应学术
必应学术中相似的文章
[Xia, Qing]的文章
[Wang, Baojie]的文章
[Liu, Mei]的文章
相关权益政策
暂无数据
收藏/分享
文件名: A new method to evaluate the effects of bacterial dosage, infection route and Vibrio strain in experimental challenges of Litopenaeus vannamei, based on the Cox proportional hazard model.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。