IOCAS-IR  > 海洋生物技术研发中心
A new method to evaluate the effects of bacterial dosage, infection route and Vibrio strain in experimental challenges of Litopenaeus vannamei, based on the Cox proportional hazard model
Xia, Qing1,2; Wang, Baojie1; Liu, Mei1; Jiang, Keyong1; Wang, Lei1
2015-10-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
Volume46Issue:2Pages:686-692
SubtypeArticle
AbstractIn the shrimp challenge test the Vibrio dosage, infection route, and strain are considered as risk factors that result in mortality. Assessment of Vibrio/shrimp interactions, and disease dynamics following infection by Vibrio, are useful techniques needed for detailed studies on the control of risk factors. In this paper we used an application of the Cox proportional hazard model to assess relative survival probability, estimate mortality risk, and construct a prognostic model to assess predictions of estimated time to death. Results indicate that infection route was the most important prognostic factor contributing to mortality in the challenge test (beta = 3.698, P < 0.000). The shrimp infection rate following injection was found to be 40.4 times greater than that following immersion (hazard ratio (HR) = 40.4; p = 0.000). Our results also indicated that the HR resulting in shrimp mortality following a high dose of 10(8) cfu/shrimp was significantly greater (HR = 5.9, P < 0.000), than that following a baseline dosage of 10(7) cfu/shrimp. Strain Vh was found to be more virulent than Strain Vp (HR = 4.8; P < 0.000). The prognostic index also indicated that the infection route is the most important prognostic factor contributing to mortality in the challenge test. (C) 2015 Elsevier Ltd. All rights reserved.
KeywordVibrio Experimental Challenges Cox Proportional Hazards (Ph) Model Mortality Prognostic Index Litopenaeus Vannamei
DOI10.1016/j.fsi.2015.07.009
Indexed BySCI
Language英语
WOS IDWOS:000363071200058
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/73941
Collection海洋生物技术研发中心
Affiliation1.Chinese Acad Sci, Inst Oceanol, Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao, Shandong, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Xia, Qing,Wang, Baojie,Liu, Mei,et al. A new method to evaluate the effects of bacterial dosage, infection route and Vibrio strain in experimental challenges of Litopenaeus vannamei, based on the Cox proportional hazard model[J]. FISH & SHELLFISH IMMUNOLOGY,2015,46(2):686-692.
APA Xia, Qing,Wang, Baojie,Liu, Mei,Jiang, Keyong,&Wang, Lei.(2015).A new method to evaluate the effects of bacterial dosage, infection route and Vibrio strain in experimental challenges of Litopenaeus vannamei, based on the Cox proportional hazard model.FISH & SHELLFISH IMMUNOLOGY,46(2),686-692.
MLA Xia, Qing,et al."A new method to evaluate the effects of bacterial dosage, infection route and Vibrio strain in experimental challenges of Litopenaeus vannamei, based on the Cox proportional hazard model".FISH & SHELLFISH IMMUNOLOGY 46.2(2015):686-692.
Files in This Item:
File Name/Size DocType Version Access License
A new method to eval(568KB)期刊论文出版稿开放获取CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xia, Qing]'s Articles
[Wang, Baojie]'s Articles
[Liu, Mei]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xia, Qing]'s Articles
[Wang, Baojie]'s Articles
[Liu, Mei]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xia, Qing]'s Articles
[Wang, Baojie]'s Articles
[Liu, Mei]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: A new method to evaluate the effects of bacterial dosage, infection route and Vibrio strain in experimental challenges of Litopenaeus vannamei, based on the Cox proportional hazard model.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.