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The transcriptomic response to copper exposure in the digestive gland of Japanese scallops (Mizuhopecten yessoensis)
Meng, Xiaolin1; Tian, Xue1; Nie, Guoxing1; Wang, Junli1; Liu, Mei2; Jiang, Keyong2; Wang, Baojie2; Guo, Qianqian1; Huang, Jianrong1; Wang, Lei2
2015-10-01
发表期刊FISH & SHELLFISH IMMUNOLOGY
卷号46期号:2页码:161-167
文章类型Article
摘要The present study was conducted to elucidate the effects of copper exposure on the immune system and lipid metabolism of the Japanese scallop, Mizuhopecten yessoensts. Transcriptional levels of differentially expressed genes (DEGs)in M. yessoensis digestive gland tissue were analyzed using the deep-sequencing platform Illumina HiSeq (TM) 2000. In total, 841 and 877 genes were identified as significantly up- or down-regulated, respectively. In addition, significant enrichment analysis identified 3 gene ontology terms and 15 pathways involved in the response to copper exposure. Analysis of transcripts related to the immune response revealed a complex pattern of innate recognition receptors, including toll-like receptors, NOD-like receptors and downstream pathway effectors, including those involved in apoptosis. Furthermore, genomic analysis revealed that genes involved in extracellular matrix (ECM)-receptor interactions were enriched in Cu-exposed scallop glands. These results will provide a resource for subsequent gene expression studies regarding heavy metal exposure and the identification of copper-sensitive biomarkers for the aquaculture of M. yessoensis. (C) 2015 Elsevier Ltd. All rights reserved.
关键词Mizuhopecten Yessoensis Digestive Gland Copper Deep-sequencing
DOI10.1016/j.fsi.2015.05.022
收录类别SCI
语种英语
WOS记录号WOS:000363071200001
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/73940
专题海洋生物技术研发中心
作者单位1.Henan Normal Univ, Coll Fisheries, Xinxiang 453007, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, R&D Ctr Marine, Qingdao 266071, Peoples R China
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Meng, Xiaolin,Tian, Xue,Nie, Guoxing,et al. The transcriptomic response to copper exposure in the digestive gland of Japanese scallops (Mizuhopecten yessoensis)[J]. FISH & SHELLFISH IMMUNOLOGY,2015,46(2):161-167.
APA Meng, Xiaolin.,Tian, Xue.,Nie, Guoxing.,Wang, Junli.,Liu, Mei.,...&Wang, Lei.(2015).The transcriptomic response to copper exposure in the digestive gland of Japanese scallops (Mizuhopecten yessoensis).FISH & SHELLFISH IMMUNOLOGY,46(2),161-167.
MLA Meng, Xiaolin,et al."The transcriptomic response to copper exposure in the digestive gland of Japanese scallops (Mizuhopecten yessoensis)".FISH & SHELLFISH IMMUNOLOGY 46.2(2015):161-167.
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