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The transcriptomic response to copper exposure in the digestive gland of Japanese scallops (Mizuhopecten yessoensis)
Meng, Xiaolin1; Tian, Xue1; Nie, Guoxing1; Wang, Junli1; Liu, Mei2; Jiang, Keyong2; Wang, Baojie2; Guo, Qianqian1; Huang, Jianrong1; Wang, Lei2
2015-10-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
Volume46Issue:2Pages:161-167
SubtypeArticle
AbstractThe present study was conducted to elucidate the effects of copper exposure on the immune system and lipid metabolism of the Japanese scallop, Mizuhopecten yessoensts. Transcriptional levels of differentially expressed genes (DEGs)in M. yessoensis digestive gland tissue were analyzed using the deep-sequencing platform Illumina HiSeq (TM) 2000. In total, 841 and 877 genes were identified as significantly up- or down-regulated, respectively. In addition, significant enrichment analysis identified 3 gene ontology terms and 15 pathways involved in the response to copper exposure. Analysis of transcripts related to the immune response revealed a complex pattern of innate recognition receptors, including toll-like receptors, NOD-like receptors and downstream pathway effectors, including those involved in apoptosis. Furthermore, genomic analysis revealed that genes involved in extracellular matrix (ECM)-receptor interactions were enriched in Cu-exposed scallop glands. These results will provide a resource for subsequent gene expression studies regarding heavy metal exposure and the identification of copper-sensitive biomarkers for the aquaculture of M. yessoensis. (C) 2015 Elsevier Ltd. All rights reserved.
KeywordMizuhopecten Yessoensis Digestive Gland Copper Deep-sequencing
DOI10.1016/j.fsi.2015.05.022
Indexed BySCI
Language英语
WOS IDWOS:000363071200001
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Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/73940
Collection海洋生物技术研发中心
Affiliation1.Henan Normal Univ, Coll Fisheries, Xinxiang 453007, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, R&D Ctr Marine, Qingdao 266071, Peoples R China
Recommended Citation
GB/T 7714
Meng, Xiaolin,Tian, Xue,Nie, Guoxing,et al. The transcriptomic response to copper exposure in the digestive gland of Japanese scallops (Mizuhopecten yessoensis)[J]. FISH & SHELLFISH IMMUNOLOGY,2015,46(2):161-167.
APA Meng, Xiaolin.,Tian, Xue.,Nie, Guoxing.,Wang, Junli.,Liu, Mei.,...&Wang, Lei.(2015).The transcriptomic response to copper exposure in the digestive gland of Japanese scallops (Mizuhopecten yessoensis).FISH & SHELLFISH IMMUNOLOGY,46(2),161-167.
MLA Meng, Xiaolin,et al."The transcriptomic response to copper exposure in the digestive gland of Japanese scallops (Mizuhopecten yessoensis)".FISH & SHELLFISH IMMUNOLOGY 46.2(2015):161-167.
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