| Synthesis of acyl thiourea derivatives of chitosan and their antimicrobial activities in vitro | |
Zhong, Zhimei1,2; Xing, Ronge1 ; Liu, Song1,2; Wang, Lin1,2; Cai, Shengbao1,2; Li, Pengcheng1,2
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| 2008-02-25 | |
| 发表期刊 | CARBOHYDRATE RESEARCH
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| ISSN | 0008-6215 |
| 卷号 | 343期号:3页码:566-570 |
| 文章类型 | Article |
| 摘要 | Three different acyl thiourea derivatives of chitosan (CS) were synthesized and their structures were characterized by FT-IR spectroscopy and elemental analysis. The antimicrobial behaviors of CS and its derivatives against four species of bacteria (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Sarcina) and four crop-threatening pathogenic fungi (Alternaria solani, Fusarium oxysporum f. sp. vasinfectum, Colletotrichum gloeosporioides (Penz.) Saec, and Phyllisticta zingiberi) were investigated. The results indicated that the antimicrobial activities of the acyl thiourea derivatives are much better than that of the parent CS. The minimum value of MIC and MBC of the derivatives against E coli was 15.62 and 62.49 mu g/mL, respectively. All of the acyl thiourea derivatives had a significant inhibitory effect on the fungi in concentrations of 50 - 500 mu g/mL; the maximum inhibitory index was 66.67%. The antifungal activities of the chloracetyl thiourea derivatives of CS are noticeably higher than the acetyl and benzoyl thiourea derivatives. The degree of grafting of the acyl thiourea group in the derivatives was related to antifungal activity; higher substitution resulted in stronger antifungal activity. (c) 2007 Elsevier Ltd. All rights reserved.; Three different acyl thiourea derivatives of chitosan (CS) were synthesized and their structures were characterized by FT-IR spectroscopy and elemental analysis. The antimicrobial behaviors of CS and its derivatives against four species of bacteria (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Sarcina) and four crop-threatening pathogenic fungi (Alternaria solani, Fusarium oxysporum f. sp. vasinfectum, Colletotrichum gloeosporioides (Penz.) Saec, and Phyllisticta zingiberi) were investigated. The results indicated that the antimicrobial activities of the acyl thiourea derivatives are much better than that of the parent CS. The minimum value of MIC and MBC of the derivatives against E coli was 15.62 and 62.49 mu g/mL, respectively. All of the acyl thiourea derivatives had a significant inhibitory effect on the fungi in concentrations of 50 - 500 mu g/mL; the maximum inhibitory index was 66.67%. The antifungal activities of the chloracetyl thiourea derivatives of CS are noticeably higher than the acetyl and benzoyl thiourea derivatives. The degree of grafting of the acyl thiourea group in the derivatives was related to antifungal activity; higher substitution resulted in stronger antifungal activity. (c) 2007 Elsevier Ltd. All rights reserved. |
| 关键词 | Antibacterial Activity Antifungal Activity Chitosan Acyl Thiourea Derivatives |
| 学科领域 | Biochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic |
| DOI | 10.1016/j.carres.2007.11.024 |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000253667500019 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/6130 |
| 专题 | 海洋生物技术研发中心 实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Zhong, Zhimei,Xing, Ronge,Liu, Song,et al. Synthesis of acyl thiourea derivatives of chitosan and their antimicrobial activities in vitro[J]. CARBOHYDRATE RESEARCH,2008,343(3):566-570. |
| APA | Zhong, Zhimei,Xing, Ronge,Liu, Song,Wang, Lin,Cai, Shengbao,&Li, Pengcheng.(2008).Synthesis of acyl thiourea derivatives of chitosan and their antimicrobial activities in vitro.CARBOHYDRATE RESEARCH,343(3),566-570. |
| MLA | Zhong, Zhimei,et al."Synthesis of acyl thiourea derivatives of chitosan and their antimicrobial activities in vitro".CARBOHYDRATE RESEARCH 343.3(2008):566-570. |
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