| Study on extraction of agaropectin from Gelidium amansii and its anticoagulant activity | |
Qi Huimin1,2; Li Daxin3; Zhang Jingjing1; Liu Li1 ; Zhang Quanbin1
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| 2008-05-01 | |
| 发表期刊 | CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
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| ISSN | 0254-4059 |
| 卷号 | 26期号:2页码:186-189 |
| 文章类型 | Article |
| 摘要 | Gelidium amansii agar was fractionated on DEAE-cellulose and four fractions were obtained sequentially. The yields of 1.0 mol/L NaCl fraction and 2.5 mol/L NaCl fraction were 2.80% and 2.03%. They are highly sulfated agar, and named as agaropectin with sulfate content being 22.8% and 32.5%, respectively. The anticoagulant experiment results show that agaropectin could effectively prolong the coagulation time in a dose-dependent manner in vitro. Agaropection could be absorbed and effectively prolong the plasma coagulation time in vivo. After intragastric administration at the doses of 100, 200, and 400 mg/kg.d in rats for 15 days, TT (thrombin time), CT (coagulation time), PT (prothrombin time), and APTT (activated partial thromboplastin time) could be effectively prolonged and the plasma Fib level could be significantly lowered.; Gelidium amansii agar was fractionated on DEAE-cellulose and four fractions were obtained sequentially. The yields of 1.0 mol/L NaCl fraction and 2.5 mol/L NaCl fraction were 2.80% and 2.03%. They are highly sulfated agar, and named as agaropectin with sulfate content being 22.8% and 32.5%, respectively. The anticoagulant experiment results show that agaropectin could effectively prolong the coagulation time in a dose-dependent manner in vitro. Agaropection could be absorbed and effectively prolong the plasma coagulation time in vivo. After intragastric administration at the doses of 100, 200, and 400 mg/kg.d in rats for 15 days, TT (thrombin time), CT (coagulation time), PT (prothrombin time), and APTT (activated partial thromboplastin time) could be effectively prolonged and the plasma Fib level could be significantly lowered. |
| 关键词 | Agar Gelidium Amansii Agaropectin Anticoagulation |
| 学科领域 | Limnology ; Oceanography |
| DOI | 10.1007/s00343-008-0186-1 |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000256416000010 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/6082 |
| 专题 | 海洋生物技术研发中心 实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Weifang Med Univ, Weifang 261042, Peoples R China 3.Shandong Prov Pharmaceut Co, Jinan 250014, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Qi Huimin,Li Daxin,Zhang Jingjing,et al. Study on extraction of agaropectin from Gelidium amansii and its anticoagulant activity[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2008,26(2):186-189. |
| APA | Qi Huimin,Li Daxin,Zhang Jingjing,Liu Li,&Zhang Quanbin.(2008).Study on extraction of agaropectin from Gelidium amansii and its anticoagulant activity.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,26(2),186-189. |
| MLA | Qi Huimin,et al."Study on extraction of agaropectin from Gelidium amansii and its anticoagulant activity".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 26.2(2008):186-189. |
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