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Evolutionary analysis of phycobiliproteins: Implications for their structural and functional relationships | |
Zhao, Fangqing; Qin, Song | |
2006-09-01 | |
发表期刊 | JOURNAL OF MOLECULAR EVOLUTION |
ISSN | 0022-2844 |
卷号 | 63期号:3页码:330-340 |
文章类型 | Article |
摘要 | Phycobiliproteins, together with linker polypeptides and various chromophores, are basic building blocks of phycobilisomes, a supramolecular complex with a light-harvesting function in cyanobacteria and red algae. Previous studies suggest that the different types of phycobiliproteins and the linker polypeptides originated from the same ancestor. Here we retrieve the phycobilisome-related genes from the well-annotated and even unfinished cyanobacteria genomes and find that many sites with elevated d(N)/d(S) ratios in different phycobiliprotein lineages are located in the chromophore-binding domain and the helical hairpin domains (X and Y). Covariation analyses also reveal that these sites are significantly correlated, showing strong evidence of the functional-structural importance of interactions among these residues. The potential selective pressure driving the diversification of phycobiliproteins may be related to the phycobiliprotein-chromophore microenvironment formation and the subunits interaction. Sites and genes identified here would provide targets for further research on the structural-functional role of these residues and energy transfer through the chromophores.; Phycobiliproteins, together with linker polypeptides and various chromophores, are basic building blocks of phycobilisomes, a supramolecular complex with a light-harvesting function in cyanobacteria and red algae. Previous studies suggest that the different types of phycobiliproteins and the linker polypeptides originated from the same ancestor. Here we retrieve the phycobilisome-related genes from the well-annotated and even unfinished cyanobacteria genomes and find that many sites with elevated d(N)/d(S) ratios in different phycobiliprotein lineages are located in the chromophore-binding domain and the helical hairpin domains (X and Y). Covariation analyses also reveal that these sites are significantly correlated, showing strong evidence of the functional-structural importance of interactions among these residues. The potential selective pressure driving the diversification of phycobiliproteins may be related to the phycobiliprotein-chromophore microenvironment formation and the subunits interaction. Sites and genes identified here would provide targets for further research on the structural-functional role of these residues and energy transfer through the chromophores. |
关键词 | Covariation Analysis Cyanobacteria Phycobiliprotein Positive Selection |
学科领域 | Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity |
DOI | 10.1007/s00239-005-0026-2 |
URL | 查看原文 |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000240797800003 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.qdio.ac.cn/handle/337002/5986 |
专题 | 实验海洋生物学重点实验室 |
作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Zhao, Fangqing,Qin, Song. Evolutionary analysis of phycobiliproteins: Implications for their structural and functional relationships[J]. JOURNAL OF MOLECULAR EVOLUTION,2006,63(3):330-340. |
APA | Zhao, Fangqing,&Qin, Song.(2006).Evolutionary analysis of phycobiliproteins: Implications for their structural and functional relationships.JOURNAL OF MOLECULAR EVOLUTION,63(3),330-340. |
MLA | Zhao, Fangqing,et al."Evolutionary analysis of phycobiliproteins: Implications for their structural and functional relationships".JOURNAL OF MOLECULAR EVOLUTION 63.3(2006):330-340. |
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