Novel antifouling and antimicrobial compound from a marine-derived fungus Ampelomyces sp.

doi:10.1007/s10126-005-6146-2

IOCAS-IR > 实验海洋生物学重点实验室

	Novel antifouling and antimicrobial compound from a marine-derived fungus Ampelomyces sp.
	Kwong, Theresa Fuk Ning ; Miao, Li ; Li, Xiancui ; Qian, Pei Yuan
	2006-11-01
发表期刊	MARINE BIOTECHNOLOGY
ISSN	1436-2228
卷号	8 期号:6 页码:634-640
文章类型	Article
摘要	In this study, using a bioassay-guided isolation and purification procedure, we obtained 3-chloro-2,5-dihydroxybenzyl alcohol from a marine-derived Ampelomyces species that effectively inhibited larval settlement of the tubeworm Hydroides elegans and of cyprids of the barnacle Balanus amphitrite. The inhibitive effect on larval settlement was nontoxic and the EC50 of 3-chloro-2,5-dihydroxybenzyl alcohol ranged from 3.19 mu g ml(-1) to 3.81 mu g ml(-1) while the LC50 was 266.68 lambda g ml(-1) for B. amphitrite cyprids; EC50 ranged from 0.67 mu g ml(-1) to 0.78 mu g ml(-1), and LC50 was 2.64 mu g ml(-1) for competent larvae of H. elegans, indicating that inhibitive effect of this compound was nontoxic. At a concentration of 50 mu g per disc, this compound showed strong inhibitive effects on the growth of 13 out of 15 marine bacterial species tested in disc diffusion bioassay. Overall, the high inhibitory activities against bacteria and larval settlement as well as the non- or low-toxic nature of this compound to the barnacle and polychaete larvae suggest this compound could be a potent antifoulant and/or antibiotic.; In this study, using a bioassay-guided isolation and purification procedure, we obtained 3-chloro-2,5-dihydroxybenzyl alcohol from a marine-derived Ampelomyces species that effectively inhibited larval settlement of the tubeworm Hydroides elegans and of cyprids of the barnacle Balanus amphitrite. The inhibitive effect on larval settlement was nontoxic and the EC50 of 3-chloro-2,5-dihydroxybenzyl alcohol ranged from 3.19 mu g ml(-1) to 3.81 mu g ml(-1) while the LC50 was 266.68 lambda g ml(-1) for B. amphitrite cyprids; EC50 ranged from 0.67 mu g ml(-1) to 0.78 mu g ml(-1), and LC50 was 2.64 mu g ml(-1) for competent larvae of H. elegans, indicating that inhibitive effect of this compound was nontoxic. At a concentration of 50 mu g per disc, this compound showed strong inhibitive effects on the growth of 13 out of 15 marine bacterial species tested in disc diffusion bioassay. Overall, the high inhibitory activities against bacteria and larval settlement as well as the non- or low-toxic nature of this compound to the barnacle and polychaete larvae suggest this compound could be a potent antifoulant and/or antibiotic.
关键词	Ampelomyces Antifouling Agent Antimicrobial Agent 3-chloro-2 5-dihydroxybenzyl Alcohol
学科领域	Biotechnology & Applied Microbiology ; Marine & Freshwater Biology
DOI	10.1007/s10126-005-6146-2
URL	查看原文
收录类别	SCI
语种	英语
WOS记录号	WOS:000243193200007
引用统计	被引频次：60[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/5962
专题	实验海洋生物学重点实验室
作者单位	1.Hong Kong Univ Sci & Technol, Dept Biol, Kowloon, Hong Kong, Peoples R China 2.Hong Kong Univ Sci & Technol, Coastal Marine Lab, Kowloon, Hong Kong, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Kwong, Theresa Fuk Ning,Miao, Li,Li, Xiancui,et al. Novel antifouling and antimicrobial compound from a marine-derived fungus Ampelomyces sp.[J]. MARINE BIOTECHNOLOGY,2006,8(6):634-640.
APA	Kwong, Theresa Fuk Ning,Miao, Li,Li, Xiancui,&Qian, Pei Yuan.(2006).Novel antifouling and antimicrobial compound from a marine-derived fungus Ampelomyces sp..MARINE BIOTECHNOLOGY,8(6),634-640.
MLA	Kwong, Theresa Fuk Ning,et al."Novel antifouling and antimicrobial compound from a marine-derived fungus Ampelomyces sp.".MARINE BIOTECHNOLOGY 8.6(2006):634-640.

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