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Structural analysis of SNARE motifs from sea perch, Lateolabrax japonicus by computerized approaches
Chen, Kui; Huang, Xiaohang
2007-10-01
发表期刊COMPUTATIONAL BIOLOGY AND CHEMISTRY
ISSN1476-9271
卷号31期号:5-6页码:378-383
文章类型Article
摘要Three cDNA sequences encoding four SNARE (N-ethylmaleimide-sensitive fusion protein attachment protein receptors) motifs were cloned from sea perch, and the deduced peptide sequences were analyzed for structural prediction by using 14 different web servers and softwares. The "ionic layer" structure, the three dimensional extension and conformational characters of the SNARE 7S core complex by using bioinformatics approaches were compared respectively with those from mammalian X-ray crystallographic investigations. The result suggested that the formation and stabilization of fish SNARE core complex might be driven by hydrophobic association, hydrogen bond among R group of core amino acids and electrostatic attraction at molecular level. This revealed that the SNARE proteins interaction of the fish may share the same molecular mechanism with that of mammal, indicating the universality and solidity of SNARE core complex theory. This work is also an attempt to get the protein 3D structural information which appears to be similar to that obtained through X-ray crystallography, only by using computerized approaches. (C) 2007 Elsevier Ltd. All rights reserved.; Three cDNA sequences encoding four SNARE (N-ethylmaleimide-sensitive fusion protein attachment protein receptors) motifs were cloned from sea perch, and the deduced peptide sequences were analyzed for structural prediction by using 14 different web servers and softwares. The "ionic layer" structure, the three dimensional extension and conformational characters of the SNARE 7S core complex by using bioinformatics approaches were compared respectively with those from mammalian X-ray crystallographic investigations. The result suggested that the formation and stabilization of fish SNARE core complex might be driven by hydrophobic association, hydrogen bond among R group of core amino acids and electrostatic attraction at molecular level. This revealed that the SNARE proteins interaction of the fish may share the same molecular mechanism with that of mammal, indicating the universality and solidity of SNARE core complex theory. This work is also an attempt to get the protein 3D structural information which appears to be similar to that obtained through X-ray crystallography, only by using computerized approaches. (C) 2007 Elsevier Ltd. All rights reserved.
关键词Sea Perch Snare Proteins Motif 7s Core Complex Protein Structure Analysis
学科领域Biology ; Computer Science, Interdisciplinary Applications
DOI10.1016/j.compbiolchem.2007.08-002
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收录类别SCI
语种英语
WOS记录号WOS:000250912400009
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/5520
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
2.State Ocean Adm, Inst Oceanog 1, Qingdao 266061, Peoples R China
3.Grad Univ Chinese Acad Sci, Beijing 100039, Peoples R China
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Chen, Kui,Huang, Xiaohang. Structural analysis of SNARE motifs from sea perch, Lateolabrax japonicus by computerized approaches[J]. COMPUTATIONAL BIOLOGY AND CHEMISTRY,2007,31(5-6):378-383.
APA Chen, Kui,&Huang, Xiaohang.(2007).Structural analysis of SNARE motifs from sea perch, Lateolabrax japonicus by computerized approaches.COMPUTATIONAL BIOLOGY AND CHEMISTRY,31(5-6),378-383.
MLA Chen, Kui,et al."Structural analysis of SNARE motifs from sea perch, Lateolabrax japonicus by computerized approaches".COMPUTATIONAL BIOLOGY AND CHEMISTRY 31.5-6(2007):378-383.
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