Immunomodulation and antitumor activity of kappa-carrageenan oligosaccharides

doi:10.1016/j.canlet.2005.11.032

	Immunomodulation and antitumor activity of kappa-carrageenan oligosaccharides
	Yuan, Huamao ; Song, Jinming; Li, Xuegang ; Li, Ning ; Dai, Jicui
	2006-11-18
发表期刊	CANCER LETTERS
ISSN	0304-3835
卷号	243 期号:2 页码:228-234
文章类型	Article
摘要	The modulation of carrageenan oligosaccharides from Kappaphycus striatum on the immune system in S 180-bearing mice was investigated. The mice inoculated with S180 cell suspension were treated p.o. with carrageenan oligosaccharides (50, 100 and 200 mu g/g) for 14 days. The effects of carrageenan oligosaccharides on transplantable tumors and macrophage phagocytosis, quantitative hemolysis of sheep red blood cells (QHS),. lymphocyte proliferation, the activity of natural killer cells (NK), production of interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-alpha) were studied. Carrageenan oligosaccharides could significantly inhibit the growth of transplantable sarcoma S180 and increase macrophage phagocytosis, the form of antibody secreted by spleen cells, spleen lymphocyte proliferation, NK cells activity, serumal IL-2 and TNF-alpha level in S 180-bearing mice. Considering all these results, it is suggested that carrageenan oligosaccharides exert their antitumor effect by promoting the immune system. (c) 2005 Elsevier Ireland Ltd. All rights reserved.; The modulation of carrageenan oligosaccharides from Kappaphycus striatum on the immune system in S 180-bearing mice was investigated. The mice inoculated with S180 cell suspension were treated p.o. with carrageenan oligosaccharides (50, 100 and 200 mu g/g) for 14 days. The effects of carrageenan oligosaccharides on transplantable tumors and macrophage phagocytosis, quantitative hemolysis of sheep red blood cells (QHS),. lymphocyte proliferation, the activity of natural killer cells (NK), production of interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-alpha) were studied. Carrageenan oligosaccharides could significantly inhibit the growth of transplantable sarcoma S180 and increase macrophage phagocytosis, the form of antibody secreted by spleen cells, spleen lymphocyte proliferation, NK cells activity, serumal IL-2 and TNF-alpha level in S 180-bearing mice. Considering all these results, it is suggested that carrageenan oligosaccharides exert their antitumor effect by promoting the immune system. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
关键词	Carrageenan Oligosaccharides Antitumor Immunomodulation
学科领域	Oncology
DOI	10.1016/j.canlet.2005.11.032
URL	查看原文
收录类别	SCI
语种	英语
WOS记录号	WOS:000242481900008
引用统计	被引频次：245[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/5488
专题	海洋生态与环境科学重点实验室
作者单位	1.Acad Sinica, Inst Oceanol, Qingdao 266071, Peoples R China 2.Acad Sinica, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Huamao,Song, Jinming,Li, Xuegang,et al. Immunomodulation and antitumor activity of kappa-carrageenan oligosaccharides[J]. CANCER LETTERS,2006,243(2):228-234.
APA	Yuan, Huamao,Song, Jinming,Li, Xuegang,Li, Ning,&Dai, Jicui.(2006).Immunomodulation and antitumor activity of kappa-carrageenan oligosaccharides.CANCER LETTERS,243(2),228-234.
MLA	Yuan, Huamao,et al."Immunomodulation and antitumor activity of kappa-carrageenan oligosaccharides".CANCER LETTERS 243.2(2006):228-234.

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