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The carbohydrate metabolism of scallop Chlamys farreri in the immune response against acute challenge of Vibrio anguillarum
Wang, Xingqiang1,2; Wang, Lingling1; Zhang, Huan1; Liu, Rui1; Song, Linsheng1
2015-10-01
Source PublicationAQUACULTURE INTERNATIONAL
Volume23Issue:5Pages:1141-1155
SubtypeArticle
AbstractCarbohydrate metabolism may play an important role in maintaining cell homeostasis in bivalves. In the present study, the temporal variations in immune and carbohydrate metabolism parameters of Zhikong scallop Chlamys farreri under an acute Vibrio anguillarum challenge were investigated in order to better understand the energetic mechanisms of scallop immune defense. After bacterial challenge, reactive oxygen species, total antioxidant capacity, acid phosphatase activity, and transcripts of peptidoglycan recognition protein and heat-shock protein 70 in the hemolymph of scallops increased substantially within 96 h. By contrast, the significantly increased malondialdehyde content was observed in the serum of challenged scallops. As far as carbohydrate metabolism was concerned, the expression levels of hexokinase, isocitrate dehydrogenase, and N-acetylglucosaminyltransferase VI in hemocytes of challenged scallops were significantly up-regulated within 192 h. At 192 h, the electron transport system budgets were significantly higher, while the glycogen contents were significantly lower in soft tissues of challenged scallops as compared to those of control. Moreover, the significantly increased glucose content concomitant with significantly up-regulated expressions of sodium glucose transporter 1 and glucose-regulated protein 78 was observed in the hemolymph at 24 h after challenge. The above results demonstrated that bacterial challenge could induce acute immune responses and cause oxidative stress in scallops. During the bacterial stress period, scallops utilized glucose via anaerobic glycolysis and aerobic oxidation to meet the overall cost of immune response. Also, scallops might rely upon the metabolic pathways of glycogen degradation and gluconeogenesis to maintain glucose homeostasis in hemolymph.
KeywordVibrio Anguillarum Glucose Metabolism Glucose Transport Glycogenolysis Immune Response Zhikong Scallop
DOI10.1007/s10499-014-9871-6
Indexed BySCI
Language英语
WOS IDWOS:000360906400002
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/50764
Collection实验海洋生物学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Huaihai Inst Technol, Jiangsu Key Lab Marine Biotechnol, Lianyungang 222005, Peoples R China
First Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Wang, Xingqiang,Wang, Lingling,Zhang, Huan,et al. The carbohydrate metabolism of scallop Chlamys farreri in the immune response against acute challenge of Vibrio anguillarum[J]. AQUACULTURE INTERNATIONAL,2015,23(5):1141-1155.
APA Wang, Xingqiang,Wang, Lingling,Zhang, Huan,Liu, Rui,&Song, Linsheng.(2015).The carbohydrate metabolism of scallop Chlamys farreri in the immune response against acute challenge of Vibrio anguillarum.AQUACULTURE INTERNATIONAL,23(5),1141-1155.
MLA Wang, Xingqiang,et al."The carbohydrate metabolism of scallop Chlamys farreri in the immune response against acute challenge of Vibrio anguillarum".AQUACULTURE INTERNATIONAL 23.5(2015):1141-1155.
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