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The broad pattern recognition spectrum of the Toll-like receptor in mollusk Zhikong scallop Chlamys farreri
Wang, Mengqiang1; Wang, Lingling1; Guo, Ying1; Sun, Rui1; Yue, Feng1; Yi, Qilin1; Song, Linsheng1,2
2015-10-01
Source PublicationDEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
Volume52Issue:2Pages:192-201
SubtypeArticle
AbstractToll-like receptors (TLRs) are among the most studied pattern recognition receptors (PRRs) playing essential roles in innate immune defenses. In the present study, the basic features of CfTLR in mollusk Zhikong scallop Chlamys jarred. including sequence homology, tissue distribution, subcellular localization and ligands spectrum, were investigated to elucidate its pattern recognition. The elements of extracellular domains (ECD) in CfTLR displayed high homology to the corresponding parts of the ECDs in TLRs from Homo sapiens. CfTLR protein was detected in hemocytes, mantle, gills, hepatopancreas, kidney and gonad of the scallops, and it was localized in both the plasma membranes and the lysosomes in HEK293T cells. MLR could activate NF kappa B in response to multiple HsTLR ligands including Pam3CSK4, glucan (GLU), peptidoglycan (PGN), polyriboinosinic:polyribocytidylic acid (poly I:C), Imiquimod and three types of CpG. Additionally, the scallop serum could enhance the induction of NF kappa B in the CfTLR expressing cells elicited by most PAMPs, including GLU, PGN, Imiquimod and four types of CpG. It could be concluded that this primitive mollusk TLR shared a hybrid function in pattern recognition and could recognize broader ligands than mammalian TLRs, and its mosaic capability of pathogen associated molecular pattern (PAMP) recognition might be based on the basic features of its structure, ligand properties and the assistance of some components in scallop serum. (C) 2015 Elsevier Ltd. All rights reserved.
KeywordChlamys Farreri Innate Immunity Pattern Recognition Toll-like Receptor
DOI10.1016/j.dci.2015.05.011
Indexed BySCI
Language英语
WOS IDWOS:000360592200010
Citation statistics
Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/50762
Collection实验海洋生物学重点实验室
Affiliation1.Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Peoples R China
2.Dalian Ocean Univ, Dalian 116023, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Wang, Mengqiang,Wang, Lingling,Guo, Ying,et al. The broad pattern recognition spectrum of the Toll-like receptor in mollusk Zhikong scallop Chlamys farreri[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2015,52(2):192-201.
APA Wang, Mengqiang.,Wang, Lingling.,Guo, Ying.,Sun, Rui.,Yue, Feng.,...&Song, Linsheng.(2015).The broad pattern recognition spectrum of the Toll-like receptor in mollusk Zhikong scallop Chlamys farreri.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,52(2),192-201.
MLA Wang, Mengqiang,et al."The broad pattern recognition spectrum of the Toll-like receptor in mollusk Zhikong scallop Chlamys farreri".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 52.2(2015):192-201.
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