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| A Nicotinamide Adenine Dinucleotide Dispersed Multi-walled Carbon Nanotubes Electrode for Direct and Selective Electrochemical Detection of Uric Acid | |
| Chen, Yan1,2; Li, Yiwei1; Ma, Yaohong1; Meng, Qingjun1; Yan, Yan1; Shi, Jianguo1 | |
| 2015-08-01 | |
| 发表期刊 | ANALYTICAL SCIENCES
 |
| 卷号 | 31期号:8页码:799-803 |
| 文章类型 | Article |
| 摘要 | A nanocomposite platform built with multi-walled carbon nanotubes (MWCNTs) and nicotinamide adenine dinucleotide (NAD(+)) via a noncovalent interaction between the large it systems in NAD(+) molecules and MWCNTs on a glassy carbon substrate was successfully developed for the sensitive and selective detection of uric acid (UA) in the presence of ascorbic acid (AA), dopamine (DA). NAD(+) has an adenine subunit and a nicotinamide subunit, which enabled interaction with the purine subunit of UA through a strong pi-pi interaction to enhance the specificity of UA. Compared with a bare glassy carbon electrode (GCE) and MWCNTs/GCE, the MWCNTs-NAD(+)/GCE showed a low background current and a remarkable enhancement of the oxidation peak current of UA. Using differential pulse voltammetry (DPV), a high sensitivity for the determination of UA was explored for the MWCNTs-NAD(+) modified electrode. A linear relationship between the DPV peak current of UA and its concentration could be obtained in the range of 0.05 - 10 mu M with the detection limit as low as 10 nM (S/N = 3). This present strategy provides a novel and promising platform for the detection of UA in human urine and serum samples. |
| 关键词 | Nanocomposite Modified Electrode Nicotinamide Adenine Dinucleotide Conjugative Effect Uric Acid |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000360256300010 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/50266 |
| 专题 | 实验海洋生物学重点实验室 |
| 作者单位 | 1.Shandong Acad Sci, Inst Biol, Lab Biosensors Shandong Prov, Jinan 250014, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Chen, Yan,Li, Yiwei,Ma, Yaohong,et al. A Nicotinamide Adenine Dinucleotide Dispersed Multi-walled Carbon Nanotubes Electrode for Direct and Selective Electrochemical Detection of Uric Acid[J]. ANALYTICAL SCIENCES,2015,31(8):799-803. |
| APA | Chen, Yan,Li, Yiwei,Ma, Yaohong,Meng, Qingjun,Yan, Yan,&Shi, Jianguo.(2015).A Nicotinamide Adenine Dinucleotide Dispersed Multi-walled Carbon Nanotubes Electrode for Direct and Selective Electrochemical Detection of Uric Acid.ANALYTICAL SCIENCES,31(8),799-803. |
| MLA | Chen, Yan,et al."A Nicotinamide Adenine Dinucleotide Dispersed Multi-walled Carbon Nanotubes Electrode for Direct and Selective Electrochemical Detection of Uric Acid".ANALYTICAL SCIENCES 31.8(2015):799-803. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| A Nicotinamide Adeni（1375KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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