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Transcription factor T-bet in Atlantic salmon: characterization and gene expression in mucosal tissues during Aeromonas salmonicida infection
Kumari, Jaya1,2; Zhang, Zuobing1,3; Swain, Trilochan1; Chi, Heng1,4; Niu, Cuijuan3; Bogwald, Jarl1; Dalmo, Roy Ambli1
2015-07-06
Source PublicationFRONTIERS IN IMMUNOLOGY
Volume6Issue:2015Pages:1-11
SubtypeArticle
AbstractThe T-box transcription factor T-bet is expressed in a number of hematopoietic cell types in mammals and plays an essential role in the lineage determination of Th1 T-helper cells and is considered as an essential feature for both innate and adaptive immune responses in higher vertebrates. In the present study, we have identified and characterized the full-length Atlantic salmon T-bet cDNA (3502 bp). The putative primary structure of the polypeptide deduced from the cDNA sequence contained 612 aa, which possessed a T-box DNA binding domain. Phylogenetic study and gene synteny revealed it is as a homolog to mammalian T-bet. Quantitative PCR analysis of different tissues in healthy fish showed that salmon T-bet gene was highly expressed in spleen, followed by head kidney, and was expressed in intestine, skin, and liver at lower levels. Moreover, the time-dependent expression profile of T-bet, interferon gamma (IFN gamma), interleukin-22 (IL-22), and natural killer enhancement factor in mucosal tissues during water-borne infection with live Aeromonas salmonicida, indicated the involvement of T-bet in mucosal immune response in Atlantic salmon.
KeywordAtlantic Salmon T-bet A. sA.monicida Gene Expression Mucosal Immunity
DOI10.3389/fimmu.2015.00345
Indexed BySCI
Language英语
WOS IDWOS:000358138500002
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/49053
Collection实验海洋生物学重点实验室
Affiliation1.Univ Tromso, Norwegian Coll Fishery Sci, Fac Biosci Fisheries & Econ, Tromso, Norway
2.NOFIMA, NO-9291 Tromso, Norway
3.Beijing Normal Univ, Coll Life Sci, Minist Educ, Key Lab Biodivers Sci & Ecol Engn, Beijing 100875, Peoples R China
4.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
Recommended Citation
GB/T 7714
Kumari, Jaya,Zhang, Zuobing,Swain, Trilochan,et al. Transcription factor T-bet in Atlantic salmon: characterization and gene expression in mucosal tissues during Aeromonas salmonicida infection[J]. FRONTIERS IN IMMUNOLOGY,2015,6(2015):1-11.
APA Kumari, Jaya.,Zhang, Zuobing.,Swain, Trilochan.,Chi, Heng.,Niu, Cuijuan.,...&Dalmo, Roy Ambli.(2015).Transcription factor T-bet in Atlantic salmon: characterization and gene expression in mucosal tissues during Aeromonas salmonicida infection.FRONTIERS IN IMMUNOLOGY,6(2015),1-11.
MLA Kumari, Jaya,et al."Transcription factor T-bet in Atlantic salmon: characterization and gene expression in mucosal tissues during Aeromonas salmonicida infection".FRONTIERS IN IMMUNOLOGY 6.2015(2015):1-11.
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