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Repertoire and evolution of TNF superfamily in Crassostrea gigas: Implications for expansion and diversification of this superfamily in Mollusca
Gao, Dahai1; Qiu, Limei1; Gao, Qiang1; Hou, Zhanhui1; Wang, Lingling1; Song, Linsheng2
2015-08-01
Source PublicationDEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
Volume51Issue:2Pages:251-260
SubtypeArticle
AbstractTumor necrosis factor superfamily (TNFSF) members represent a group of cytokines participating in diverse immunological, pathological and developmental pathways. However, compared with deuterostomia and cnidaia, the composition and evolution of TNF homologous in protostomia are still not well understood. In the present study, a total of 81 TNF superfamily (TNFSF) genes from 15 mollusk species, including 23 TNFSF genes from Crassostrea gigas, were surveyed by genome-wide bioinformatics analysis. The phylogenetic analysis showed that 14 out of 23 C. gigas TNFSF genes in five clades exhibited orthologous relationships with Pinctada fucata TNFSF genes. Moreover, there were 15 C. gigas TNFSF genes located in oyster-specific clusters, which were contributed by small-scaled tandem and/or segmental duplication events in oyster. By comparing the sequences of duplicated TNFSF pairs, exon loss and variant in exon/intron length were revealed as the major modes of divergence in gene structure. Most of the duplicated C. gigas TNFSF pairs were evolved under purifying selection with consistent tissue expression patterns, implying functional constraint shaped diversification. This study demonstrated the expansion and early divergence of TNF superfamily in C. gigas, which provides potential insight into revealing the evolution and function of this superfamily in mollusk. (C) 2015 Elsevier Ltd. All rights reserved.
KeywordCrassostrea Gigas Tnfsf Gene Phylogenetic Analysis Gene Duplication Diversification
DOI10.1016/j.dci.2015.04.006
Indexed BySCI
Language英语
WOS IDWOS:000357910600004
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/49051
Collection实验海洋生物学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Dalian Ocean Univ, Dalian 116023, Peoples R China
First Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Gao, Dahai,Qiu, Limei,Gao, Qiang,et al. Repertoire and evolution of TNF superfamily in Crassostrea gigas: Implications for expansion and diversification of this superfamily in Mollusca[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2015,51(2):251-260.
APA Gao, Dahai,Qiu, Limei,Gao, Qiang,Hou, Zhanhui,Wang, Lingling,&Song, Linsheng.(2015).Repertoire and evolution of TNF superfamily in Crassostrea gigas: Implications for expansion and diversification of this superfamily in Mollusca.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,51(2),251-260.
MLA Gao, Dahai,et al."Repertoire and evolution of TNF superfamily in Crassostrea gigas: Implications for expansion and diversification of this superfamily in Mollusca".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 51.2(2015):251-260.
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