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Characterization of an inhibitor of apoptosis protein in Crassostrea gigas clarifies its role in apoptosis and immune defense
Qu, Tao1; Zhang, Linlin1; Wang, Wei1; Huang, Baoyu1,2; Li, Yingxiang1,2; Zhu, Qihui1,2; Li, Li1; Zhang, Guofan1
2015-07-01
Source PublicationDEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
Volume51Issue:1Pages:74-78
SubtypeArticle
AbstractThe inhibitor of apoptosis (IAP) proteins maintain a balance between cell proliferation and cell death by inhibiting caspase activity and facilitating immune responses. In this study, phylogenetic analysis revealed lineage-specific expansion and tandem duplication of IAPs in the Pacific oyster Crassostrea gigas. We then investigated a representative oyster-specific XIAP-like gene (CgIAP2) to understand how it regulates initiator caspase. Cloning of full-length CgIAP2 from oyster cDNA uncovered a deduced protein containing two BIR domains and a RING domain. Homolog comparison demonstrated that CgIAP2 clustered into the invertebrate branch. We found that CgIAP2 was likely involved in apoptosis inhibition and immune defense, based on high mRNA expression in the gills and labial palps, as well as increased mRNA expression after bacterial challenge. A yeast two-hybrid assay revealed that the BIR2 domain was necessary and sufficient to mediate interaction between CgIAP2 and Cgcaspase-2, providing direct evidence that CgIAP2 participates in apoptosis inhibition. (C) 2015 Elsevier Ltd. All rights reserved.
KeywordCrassostrea Gigas Iap Evolution Intrinsic Apoptosis Caspase Immune Response
DOI10.1016/j.dci.2015.02.011
Indexed BySCI
Language英语
WOS IDWOS:000357906800009
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/49050
Collection海洋生物技术研发中心
实验海洋生物学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Qu, Tao,Zhang, Linlin,Wang, Wei,et al. Characterization of an inhibitor of apoptosis protein in Crassostrea gigas clarifies its role in apoptosis and immune defense[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2015,51(1):74-78.
APA Qu, Tao.,Zhang, Linlin.,Wang, Wei.,Huang, Baoyu.,Li, Yingxiang.,...&Zhang, Guofan.(2015).Characterization of an inhibitor of apoptosis protein in Crassostrea gigas clarifies its role in apoptosis and immune defense.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,51(1),74-78.
MLA Qu, Tao,et al."Characterization of an inhibitor of apoptosis protein in Crassostrea gigas clarifies its role in apoptosis and immune defense".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 51.1(2015):74-78.
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