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Anti-Angiogenic Properties of BDDPM, a Bromophenol from Marine Red Alga Rhodomela confervoides, with Multi Receptor Tyrosine Kinase Inhibition Effects
Wang, Shuaiyu; Wang, Li-Jun; Jiang, Bo; Wu, Ning; Li, Xiangqian; Liu, Shaofang; Luo, Jiao; Shi, Dayong
2015-06-01
Source PublicationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume16Issue:6Pages:13548-13560
SubtypeArticle
AbstractBis-(2,3-dibromo-4,5-dihydroxy-phenyl)-methane (BDDPM) is a bromophenol first isolated from Rhodomelaceae confervoides. Our previous studies showed that BDDPM exerts PTP1B-inhibiting activity and anti-cancer activity against a wide range of tumor cells while it also showed lower cytotoxicity against normal cells. In the present study, we found that BDDPM exhibits significant activities toward angiogenesis in vitro. BDDPM inhibits multiple angiogenesis processes, including endothelial cell sprouting, migration, proliferation, and tube formation. Further kinase assays investigations found that BDDPM is a potent selective, but multi-target, receptor tyrosine kinase (RTKs) inhibitor. BDDPM (10 mu M) inhibits the activities of fibroblast growth factor receptor 2 and 3 (FGFR2, 3), vascular endothelial growth factor receptor 2 (VEGFR2) and platelet-derived growth factor receptor alpha (PDGFR alpha) (inhibition rate: 57.7%, 78.6%, 78.5% and 71.1%, respectively). Moreover, BDDPM also decreases the phosphorylation of protein kinase B (PKB/Akt) and endothelial nitric oxide synthase (eNOS), as well as nitric oxide (NO) production in a dose dependent manner. These results indicate that BDDPM can be exploited as an anti-angiogenic drug, or as a lead compound for the development of novel multi-target RTKs inhibitors.
DOI10.3390/ijms160613548
Indexed BySCI
Language英语
WOS IDWOS:000357492800092
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/48989
Collection海洋生物技术研发中心
AffiliationChinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Wang, Shuaiyu,Wang, Li-Jun,Jiang, Bo,et al. Anti-Angiogenic Properties of BDDPM, a Bromophenol from Marine Red Alga Rhodomela confervoides, with Multi Receptor Tyrosine Kinase Inhibition Effects[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2015,16(6):13548-13560.
APA Wang, Shuaiyu.,Wang, Li-Jun.,Jiang, Bo.,Wu, Ning.,Li, Xiangqian.,...&Shi, Dayong.(2015).Anti-Angiogenic Properties of BDDPM, a Bromophenol from Marine Red Alga Rhodomela confervoides, with Multi Receptor Tyrosine Kinase Inhibition Effects.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,16(6),13548-13560.
MLA Wang, Shuaiyu,et al."Anti-Angiogenic Properties of BDDPM, a Bromophenol from Marine Red Alga Rhodomela confervoides, with Multi Receptor Tyrosine Kinase Inhibition Effects".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 16.6(2015):13548-13560.
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