| Fucoidan inhibits the development of proteinuria in active Heymann nephritis | |
| Zhang, QB; Li, N; Zhao, TT; Qi, HM; Xu, ZH; Li, Z | |
| 2005 | |
| 发表期刊 | PHYTOTHERAPY RESEARCH
 |
| ISSN | 0951-418X |
| 卷号 | 19期号:1页码:50-53 |
| 文章类型 | Article |
| 摘要 | Fucoidan, the sulphated polysaccharide extracted from brown seaweed, has various biological activities. The effect of fucoidan on the formation of proteinuria and renal functions in active Heymann nephritis was investigated in this study. Active Heymann nephritis was induced by administering brush border protein of rat proximal uriniferous tubules (FX1A). Fucoidan was administered by oral intubation to Heymann nephritis rats at three doses (50, 100 and 200 mg/kg) once daily for 4 weeks. The elevated urinary protein excretion and plasma creatinine due to the induction of Heymann nephritis were significantly reduced by fucoidan at doses of 100 and 200 mg/kg. The results indicated that fucoidan has a renoprotective effect on active Heymann nephritis and is a promising therapeutic agent for nephritis. Copyright (c) 2005 John Wiley F Sons, Ltd.; Fucoidan, the sulphated polysaccharide extracted from brown seaweed, has various biological activities. The effect of fucoidan on the formation of proteinuria and renal functions in active Heymann nephritis was investigated in this study. Active Heymann nephritis was induced by administering brush border protein of rat proximal uriniferous tubules (FX1A). Fucoidan was administered by oral intubation to Heymann nephritis rats at three doses (50, 100 and 200 mg/kg) once daily for 4 weeks. The elevated urinary protein excretion and plasma creatinine due to the induction of Heymann nephritis were significantly reduced by fucoidan at doses of 100 and 200 mg/kg. The results indicated that fucoidan has a renoprotective effect on active Heymann nephritis and is a promising therapeutic agent for nephritis. Copyright (c) 2005 John Wiley F Sons, Ltd. |
| 关键词 | Fucoidan Laminaria Japonica Laminariales Proteinuria Heymann Nephritis |
| 学科领域 | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| DOI | 10.1002/ptr.1623 |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000228049900007 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/3558 |
| 专题 | 海洋生物技术研发中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, QB,Li, N,Zhao, TT,et al. Fucoidan inhibits the development of proteinuria in active Heymann nephritis[J]. PHYTOTHERAPY RESEARCH,2005,19(1):50-53. |
| APA | Zhang, QB,Li, N,Zhao, TT,Qi, HM,Xu, ZH,&Li, Z.(2005).Fucoidan inhibits the development of proteinuria in active Heymann nephritis.PHYTOTHERAPY RESEARCH,19(1),50-53. |
| MLA | Zhang, QB,et al."Fucoidan inhibits the development of proteinuria in active Heymann nephritis".PHYTOTHERAPY RESEARCH 19.1(2005):50-53. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| zhang-Fucoidan inhib（100KB） | 限制开放 | -- | 浏览 | |||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论