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Biological effect of R-phycoerythrin-mediated photosensitization on DNA.
Li, GW; Li, ZG
2000
发表期刊PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
ISSN1000-3282
卷号27期号:6页码:621-624
摘要R-phycoerythrin (R-PE) is one of important proteins involved in capturing light during photosynthesis in red algae, and it is highly fluorescent, and water-soluble chromophores. In vivo, it can transfer the light energy into photosynthetic center, however, it can deliver the captured light energy captured to the surrounding oxygen in vitro and produce reactive oxygen species such as singlet oxygen, which is toxic to tumor cells. R-PE was added to the culture medium of tumor cells, subsequently with irradiation of 488 nm, Argon laser of 25.6 J/cm(2). The result by MTT assay showed that the survival rate decreased with the increase of R-PE concentration from 1 to 100 mg/L. The result from H-3-TdR incorporation demonstrated that the synthesis of DNA reduced when the concentration of R-PE increased from 0.01 to 0.32 mg/L. Besides, pUC18 DNA showed a conversion from supercoiled into linear conformation. The conclusion comes that R-PE mediated PDT can influence the conformation of DNA, and it may be one of the mechanisms of R-PE mediated photodynamic therapy.
学科领域Biochemistry & Molecular Biology ; Biophysics
收录类别sci
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/3342
专题实验海洋生物学重点实验室
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Li, GW,Li, ZG. Biological effect of R-phycoerythrin-mediated photosensitization on DNA.[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2000,27(6):621-624.
APA Li, GW,&Li, ZG.(2000).Biological effect of R-phycoerythrin-mediated photosensitization on DNA..PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,27(6),621-624.
MLA Li, GW,et al."Biological effect of R-phycoerythrin-mediated photosensitization on DNA.".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 27.6(2000):621-624.
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