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New indole-diterpenoids from the algal-associated fungus Aspergillus nidulans
Zhang, Peng1,2; Li, Xiao-Ming1; Li, Xin1,2; Wang, Bin-Gui1
2015-06-01
发表期刊PHYTOCHEMISTRY LETTERS
卷号12页码:182-185
文章类型Article
摘要Two new compounds, including a chlorinated indole-diterpenoid 19-hydroxypenitrem A (1) and its dechlorinated derivative 19-hydroxypenitrem E (2), along with two known congeners (3 and 4), were isolated and identified from the cultures of Aspergillus nidulans EN-330, an endophytic fungus obtained from the marine red alga Polysiphonia scopulorum var. villum. Their structures and absolute configurations were assigned on the basis of 1D and 2D NMR and CD experiments. Compounds 1-4 exhibited cytotoxic activity against brine shrimp with LD50 values of 3.2, 4.6, 1.7, and 8.7 mu M, respectively. Besides, the chlorinated 19-hydroxypenitrem A (1) showed antimicrobial activity against four human-and aqua-pathogens. Preliminary SAR study revealed that the Cl-substitution at C-6 enhanced the cytotoxic activity against brine shrimp and antimicrobial activity, while the 19-OH substitution suppressed the activity. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
关键词Indole-diterpenoids Marine Algal-derived Fungus Polysiphonia Scopulorum Var. Villum Aspergillus Nidulans Cytotoxic Against Brine Shrimp Antimicrobial Activity
DOI10.1016/j.phytol.2015.03.017
收录类别SCI
语种英语
WOS记录号WOS:000356336400035
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/33085
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Zhang, Peng,Li, Xiao-Ming,Li, Xin,et al. New indole-diterpenoids from the algal-associated fungus Aspergillus nidulans[J]. PHYTOCHEMISTRY LETTERS,2015,12:182-185.
APA Zhang, Peng,Li, Xiao-Ming,Li, Xin,&Wang, Bin-Gui.(2015).New indole-diterpenoids from the algal-associated fungus Aspergillus nidulans.PHYTOCHEMISTRY LETTERS,12,182-185.
MLA Zhang, Peng,et al."New indole-diterpenoids from the algal-associated fungus Aspergillus nidulans".PHYTOCHEMISTRY LETTERS 12(2015):182-185.
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