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New indole-diterpenoids from the algal-associated fungus Aspergillus nidulans
Zhang, Peng1,2; Li, Xiao-Ming1; Li, Xin1,2; Wang, Bin-Gui1
2015-06-01
Source PublicationPHYTOCHEMISTRY LETTERS
Volume12Pages:182-185
SubtypeArticle
AbstractTwo new compounds, including a chlorinated indole-diterpenoid 19-hydroxypenitrem A (1) and its dechlorinated derivative 19-hydroxypenitrem E (2), along with two known congeners (3 and 4), were isolated and identified from the cultures of Aspergillus nidulans EN-330, an endophytic fungus obtained from the marine red alga Polysiphonia scopulorum var. villum. Their structures and absolute configurations were assigned on the basis of 1D and 2D NMR and CD experiments. Compounds 1-4 exhibited cytotoxic activity against brine shrimp with LD50 values of 3.2, 4.6, 1.7, and 8.7 mu M, respectively. Besides, the chlorinated 19-hydroxypenitrem A (1) showed antimicrobial activity against four human-and aqua-pathogens. Preliminary SAR study revealed that the Cl-substitution at C-6 enhanced the cytotoxic activity against brine shrimp and antimicrobial activity, while the 19-OH substitution suppressed the activity. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
KeywordIndole-diterpenoids Marine Algal-derived Fungus Polysiphonia Scopulorum Var. Villum Aspergillus Nidulans Cytotoxic Against Brine Shrimp Antimicrobial Activity
DOI10.1016/j.phytol.2015.03.017
Indexed BySCI
Language英语
WOS IDWOS:000356336400035
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/33085
Collection实验海洋生物学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
First Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhang, Peng,Li, Xiao-Ming,Li, Xin,et al. New indole-diterpenoids from the algal-associated fungus Aspergillus nidulans[J]. PHYTOCHEMISTRY LETTERS,2015,12:182-185.
APA Zhang, Peng,Li, Xiao-Ming,Li, Xin,&Wang, Bin-Gui.(2015).New indole-diterpenoids from the algal-associated fungus Aspergillus nidulans.PHYTOCHEMISTRY LETTERS,12,182-185.
MLA Zhang, Peng,et al."New indole-diterpenoids from the algal-associated fungus Aspergillus nidulans".PHYTOCHEMISTRY LETTERS 12(2015):182-185.
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