| Antidiabetic Activity of Differently Regioselective Chitosan Sulfates in Alloxan-Induced Diabetic Rats | |
Xing, Ronge1 ; He, Xiaofei1,2; Liu, Song1; Yu, Huahua1; Qin, Yukun1; Chen, Xiaolin1; Li, Kecheng1; Li, Rongfeng1; Li, Pengcheng1
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| 2015-05-01 | |
| 发表期刊 | MARINE DRUGS
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| 卷号 | 13期号:5页码:3072-3090 |
| 文章类型 | Article |
| 摘要 | The present study investigated and compared the hypoglycemic activity of differently regioselective chitosan sulfates in alloxan-induced diabetic rats. Compared with the normal control rats, significantly higher blood glucose levels were observed in the alloxan-induced diabetic rats. The differently regioselective chitosan sulfates exhibited hypoglycemic activities at different doses and intervals, especially 3-O-sulfochitosan (3-S). The major results are as follows. First, 3,6-di-O-sulfochitosan and 3-O-sulfochitosan exhibited more significant hypoglycemic activities than 2-N-3, 6-di-O-sulfochitosan and 6-O-sulfochitosan. Moreover, 3-S-treated rats showed a more significant reduction of blood glucose levels than those treated by 3,6-di-O-sulfochitosan. These results indicated that -OSO3- at the C3-position of chitosan is a key active site. Second, 3-S significantly reduced the blood glucose levels and regulated the glucose tolerance effect in the experimental rats. Third, treatment with 3-S significantly increased the plasma insulin levels in the experimental diabetic rats. A noticeable hypoglycemic activity of 3-S in the alloxan-induced diabetic rats was shown. Clinical trials are required in the future to confirm the utility of 3-S. |
| 关键词 | Differently Regioselective Chitosan Sulfates Hypoglycemic Activity Glucose Tolerance Plasma Insulin Alloxan-induced Diabetic Rats |
| DOI | 10.3390/md13053072 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000356241100026 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/33078 |
| 专题 | 海洋生物技术研发中心 海洋环境工程技术研究发展中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Coll Earth Sci, Beijing 100049, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Xing, Ronge,He, Xiaofei,Liu, Song,et al. Antidiabetic Activity of Differently Regioselective Chitosan Sulfates in Alloxan-Induced Diabetic Rats[J]. MARINE DRUGS,2015,13(5):3072-3090. |
| APA | Xing, Ronge.,He, Xiaofei.,Liu, Song.,Yu, Huahua.,Qin, Yukun.,...&Li, Pengcheng.(2015).Antidiabetic Activity of Differently Regioselective Chitosan Sulfates in Alloxan-Induced Diabetic Rats.MARINE DRUGS,13(5),3072-3090. |
| MLA | Xing, Ronge,et al."Antidiabetic Activity of Differently Regioselective Chitosan Sulfates in Alloxan-Induced Diabetic Rats".MARINE DRUGS 13.5(2015):3072-3090. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Antidiabetic Activit（919KB） | 期刊论文 | 出版稿 | 限制开放 | ODC PDDL | 浏览 | |
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