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Antidiabetic Activity of Differently Regioselective Chitosan Sulfates in Alloxan-Induced Diabetic Rats
Xing, Ronge1; He, Xiaofei1,2; Liu, Song1; Yu, Huahua1; Qin, Yukun1; Chen, Xiaolin1; Li, Kecheng1; Li, Rongfeng1; Li, Pengcheng1
2015-05-01
发表期刊MARINE DRUGS
卷号13期号:5页码:3072-3090
文章类型Article
摘要The present study investigated and compared the hypoglycemic activity of differently regioselective chitosan sulfates in alloxan-induced diabetic rats. Compared with the normal control rats, significantly higher blood glucose levels were observed in the alloxan-induced diabetic rats. The differently regioselective chitosan sulfates exhibited hypoglycemic activities at different doses and intervals, especially 3-O-sulfochitosan (3-S). The major results are as follows. First, 3,6-di-O-sulfochitosan and 3-O-sulfochitosan exhibited more significant hypoglycemic activities than 2-N-3, 6-di-O-sulfochitosan and 6-O-sulfochitosan. Moreover, 3-S-treated rats showed a more significant reduction of blood glucose levels than those treated by 3,6-di-O-sulfochitosan. These results indicated that -OSO3- at the C3-position of chitosan is a key active site. Second, 3-S significantly reduced the blood glucose levels and regulated the glucose tolerance effect in the experimental rats. Third, treatment with 3-S significantly increased the plasma insulin levels in the experimental diabetic rats. A noticeable hypoglycemic activity of 3-S in the alloxan-induced diabetic rats was shown. Clinical trials are required in the future to confirm the utility of 3-S.
关键词Differently Regioselective Chitosan Sulfates Hypoglycemic Activity Glucose Tolerance Plasma Insulin Alloxan-induced Diabetic Rats
DOI10.3390/md13053072
收录类别SCI
语种英语
WOS记录号WOS:000356241100026
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/33078
专题海洋生物技术研发中心
海洋环境工程技术研究发展中心
作者单位1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Coll Earth Sci, Beijing 100049, Peoples R China
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GB/T 7714
Xing, Ronge,He, Xiaofei,Liu, Song,et al. Antidiabetic Activity of Differently Regioselective Chitosan Sulfates in Alloxan-Induced Diabetic Rats[J]. MARINE DRUGS,2015,13(5):3072-3090.
APA Xing, Ronge.,He, Xiaofei.,Liu, Song.,Yu, Huahua.,Qin, Yukun.,...&Li, Pengcheng.(2015).Antidiabetic Activity of Differently Regioselective Chitosan Sulfates in Alloxan-Induced Diabetic Rats.MARINE DRUGS,13(5),3072-3090.
MLA Xing, Ronge,et al."Antidiabetic Activity of Differently Regioselective Chitosan Sulfates in Alloxan-Induced Diabetic Rats".MARINE DRUGS 13.5(2015):3072-3090.
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