| Synthesis and characterization of biodegradable thermoresponsive N-maleyl gelatin-co-P(N-isopropylacrylamide) hydrogel cross-linked with Bis-acrylamide for control release | |
| Zheng, Yi1; Wang, Baojie2; Liu, Mei2; Jiang, Keyong2; Wang, Lei2; Yu, Yueqin1 | |
| 2015-06-01 | |
| 发表期刊 | COLLOID AND POLYMER SCIENCE
 |
| 卷号 | 293期号:6页码:1615-1621 |
| 文章类型 | Article |
| 摘要 | Biodegradable N-maleyl gelatin (N-MAGEL) was synthesized with gelatin (GEL) and maleic anhydride (MAH) by acylation. With Bis-acrylamide (Bis) cross-linker, a series of cross-linked poly (N-isopropylacrylamide-co-N-maleyl gelatin) [P(NIPAAm-co-N-MAGEL)] hydrogels were prepared, and their lower critical solution temperature (LCST), water content, swelling/deswelling kinetics, drug delivery behaviors, and enzymatic degradation properties were investigated. As weight ratios of N-MAGEL/NIPAAm in hydrogel were increasing, water content increased, and it had no significant influence on LCST of hydrogel in spite of the weight ratios reaching 30:70. In the swelling/deswelling kinetics, hydrogels with higher weight ratios of N-MAGEL/NIPAAm exhibited faster swelling rate and slower deswelling rate. Drug delivery for bovine serum albumin (BSA) research indicated that increasing weight ratios of N-MAGEL/NIPAAm in hydrogels contribute to raising release time and cumulative release ratios. Lastly, hydrogels with higher weight ratios of N-MAGEL/NIPAAm degraded rapidly in phosphate-buffered saline (PBS) containing papain. |
| 关键词 | N-maleyl Gelatin N-isopropylacrylamide Swelling/deswelling Kinetics Release Enzymatic Degradation |
| DOI | 10.1007/s00396-015-3544-5 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000355334600004 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/33061 |
| 专题 | 海洋生物技术研发中心 |
| 作者单位 | 1.Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Key Lab Ecochem Engn, Qingdao 266042, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Yi,Wang, Baojie,Liu, Mei,et al. Synthesis and characterization of biodegradable thermoresponsive N-maleyl gelatin-co-P(N-isopropylacrylamide) hydrogel cross-linked with Bis-acrylamide for control release[J]. COLLOID AND POLYMER SCIENCE,2015,293(6):1615-1621. |
| APA | Zheng, Yi,Wang, Baojie,Liu, Mei,Jiang, Keyong,Wang, Lei,&Yu, Yueqin.(2015).Synthesis and characterization of biodegradable thermoresponsive N-maleyl gelatin-co-P(N-isopropylacrylamide) hydrogel cross-linked with Bis-acrylamide for control release.COLLOID AND POLYMER SCIENCE,293(6),1615-1621. |
| MLA | Zheng, Yi,et al."Synthesis and characterization of biodegradable thermoresponsive N-maleyl gelatin-co-P(N-isopropylacrylamide) hydrogel cross-linked with Bis-acrylamide for control release".COLLOID AND POLYMER SCIENCE 293.6(2015):1615-1621. |
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