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Synthesis and characterization of biodegradable thermoresponsive N-maleyl gelatin-co-P(N-isopropylacrylamide) hydrogel cross-linked with Bis-acrylamide for control release
Zheng, Yi1; Wang, Baojie2; Liu, Mei2; Jiang, Keyong2; Wang, Lei2; Yu, Yueqin1
2015-06-01
Source PublicationCOLLOID AND POLYMER SCIENCE
Volume293Issue:6Pages:1615-1621
SubtypeArticle
AbstractBiodegradable N-maleyl gelatin (N-MAGEL) was synthesized with gelatin (GEL) and maleic anhydride (MAH) by acylation. With Bis-acrylamide (Bis) cross-linker, a series of cross-linked poly (N-isopropylacrylamide-co-N-maleyl gelatin) [P(NIPAAm-co-N-MAGEL)] hydrogels were prepared, and their lower critical solution temperature (LCST), water content, swelling/deswelling kinetics, drug delivery behaviors, and enzymatic degradation properties were investigated. As weight ratios of N-MAGEL/NIPAAm in hydrogel were increasing, water content increased, and it had no significant influence on LCST of hydrogel in spite of the weight ratios reaching 30:70. In the swelling/deswelling kinetics, hydrogels with higher weight ratios of N-MAGEL/NIPAAm exhibited faster swelling rate and slower deswelling rate. Drug delivery for bovine serum albumin (BSA) research indicated that increasing weight ratios of N-MAGEL/NIPAAm in hydrogels contribute to raising release time and cumulative release ratios. Lastly, hydrogels with higher weight ratios of N-MAGEL/NIPAAm degraded rapidly in phosphate-buffered saline (PBS) containing papain.
KeywordN-maleyl Gelatin N-isopropylacrylamide Swelling/deswelling Kinetics Release Enzymatic Degradation
DOI10.1007/s00396-015-3544-5
Indexed BySCI
Language英语
WOS IDWOS:000355334600004
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/33061
Collection海洋生物技术研发中心
Affiliation1.Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Key Lab Ecochem Engn, Qingdao 266042, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
Recommended Citation
GB/T 7714
Zheng, Yi,Wang, Baojie,Liu, Mei,et al. Synthesis and characterization of biodegradable thermoresponsive N-maleyl gelatin-co-P(N-isopropylacrylamide) hydrogel cross-linked with Bis-acrylamide for control release[J]. COLLOID AND POLYMER SCIENCE,2015,293(6):1615-1621.
APA Zheng, Yi,Wang, Baojie,Liu, Mei,Jiang, Keyong,Wang, Lei,&Yu, Yueqin.(2015).Synthesis and characterization of biodegradable thermoresponsive N-maleyl gelatin-co-P(N-isopropylacrylamide) hydrogel cross-linked with Bis-acrylamide for control release.COLLOID AND POLYMER SCIENCE,293(6),1615-1621.
MLA Zheng, Yi,et al."Synthesis and characterization of biodegradable thermoresponsive N-maleyl gelatin-co-P(N-isopropylacrylamide) hydrogel cross-linked with Bis-acrylamide for control release".COLLOID AND POLYMER SCIENCE 293.6(2015):1615-1621.
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