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Natural and semisynthetic protein tyrosine phosphatase 1B (PTP1B) inhibitors as anti-diabetic agents
Wang, Li-Jun; Jiang, Bo; Wu, Ning; Wang, Shuai-Yu; Shi, Da-Yong
2015
Source PublicationRSC ADVANCES
Volume5Issue:60Pages:48822-48834
SubtypeReview
AbstractDiabetes mellitus, which includes both type 1 and type 2 diabetes mellitus (T2DM), is a major disease that threatens human health worldwide. Protein tyrosine phosphatase 1B (PTP1B) is a promising molecular-level therapeutic target that is effective in the management of T2DM. Natural products with various skeletons and diverse bioactivities offer opportunities for the development of new drugs and lead compounds with potent inhibitory activity against PTP1B in vitro and in vivo. Recently, a number of potent PTP1B inhibitors have been obtained from natural sources or prepared by synthesis/semisynthesis, and they exhibit potential for the treatment of T2DM. In this review, we discuss the development of potent natural and semisynthetic PTP1B inhibitors with IC50 values under 10 mu M over the past six years (2009-2014), including their structural features, biological features, structure-activity relationships (SARs). We also discuss strategies for identifying potent PTP1B inhibitors from natural products to provide useful information for use by medicinal chemists in developing potent PTP1B inhibitors as T2DM treatments.
DOI10.1039/c5ra01754h
Indexed BySCI
Language英语
WOS IDWOS:000355738300078
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/33057
Collection海洋生物技术研发中心
AffiliationChinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Wang, Li-Jun,Jiang, Bo,Wu, Ning,et al. Natural and semisynthetic protein tyrosine phosphatase 1B (PTP1B) inhibitors as anti-diabetic agents[J]. RSC ADVANCES,2015,5(60):48822-48834.
APA Wang, Li-Jun,Jiang, Bo,Wu, Ning,Wang, Shuai-Yu,&Shi, Da-Yong.(2015).Natural and semisynthetic protein tyrosine phosphatase 1B (PTP1B) inhibitors as anti-diabetic agents.RSC ADVANCES,5(60),48822-48834.
MLA Wang, Li-Jun,et al."Natural and semisynthetic protein tyrosine phosphatase 1B (PTP1B) inhibitors as anti-diabetic agents".RSC ADVANCES 5.60(2015):48822-48834.
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