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Reinforcing the Egg-Timer: Recruitment of Novel Lophotrochozoa Homeobox Genes to Early and Late Development in the Pacific Oyster
Paps, Jordi1; Xu, Fei2; Zhang, Guofan2; Holland, Peter W. H.1
2015-03-01
Source PublicationGENOME BIOLOGY AND EVOLUTION
Volume7Issue:3Pages:677-688
SubtypeArticle
AbstractThe metazoan superclade Lophotrochozoa includes mollusks, annelids, and several other animal phyla. It is reasonable to assume that this organismal diversity may be traced, in part, to changes in developmentally important genes, such as the homeobox genes. Although most comparative studies have focussed on ancient homeobox gene families conserved across bilaterians, there are also "novel" homeobox genes that have arisen more recently in evolution, presumably by duplication followed by radical divergence and functional change. We classify 136 homeobox genes in the genome sequence of the Pacific oyster, Crassostrea gigas. The genome shows an unusually low degree of homeobox gene clustering, with disruption of the NK, Hox, and ParaHox gene clusters. Among the oyster genes, 31 do not fall into ancient metazoan or bilaterian homeobox gene families; we deduce that they originated in the lophotrochozoan clade. We compared eight lophotrochozoan genomes to trace the pattern of homeobox gene evolution across this clade, allowing us to define 19 new lophotrochozoan-specific clades within the ANTP, PRD, TALE, ZF, SIX, and CUT classes. Using transcriptome data, we compared temporal expression of each homeobox gene in oyster development, and discovered that the lophotrochozoan-specific homeobox genes have peak expressio neither in early development (egg to gastrula) or in late development (after the trochophore larval stage), but rarely in between. This finding is consistent with the egg-timer, hourglass or phylotypic stage model of developmental evolution, in which there is a conserved central phase of development, but more evolutionarily labile early and late phases.
KeywordGene Duplication Gene Families Annelida Mollusca Platyhelminthes Rotifera Homeodomain
DOI10.1093/gbe/evv018
Indexed BySCI
Language英语
WOS IDWOS:000354750300005
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/33036
Collection海洋生物技术研发中心
Affiliation1.Univ Oxford, Dept Zool, Oxford OX1 2JD, England
2.Chinese Acad Sci, Inst Oceanol, Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao, Peoples R China
Recommended Citation
GB/T 7714
Paps, Jordi,Xu, Fei,Zhang, Guofan,et al. Reinforcing the Egg-Timer: Recruitment of Novel Lophotrochozoa Homeobox Genes to Early and Late Development in the Pacific Oyster[J]. GENOME BIOLOGY AND EVOLUTION,2015,7(3):677-688.
APA Paps, Jordi,Xu, Fei,Zhang, Guofan,&Holland, Peter W. H..(2015).Reinforcing the Egg-Timer: Recruitment of Novel Lophotrochozoa Homeobox Genes to Early and Late Development in the Pacific Oyster.GENOME BIOLOGY AND EVOLUTION,7(3),677-688.
MLA Paps, Jordi,et al."Reinforcing the Egg-Timer: Recruitment of Novel Lophotrochozoa Homeobox Genes to Early and Late Development in the Pacific Oyster".GENOME BIOLOGY AND EVOLUTION 7.3(2015):677-688.
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