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Reinforcing the Egg-Timer: Recruitment of Novel Lophotrochozoa Homeobox Genes to Early and Late Development in the Pacific Oyster
Paps, Jordi1; Xu, Fei2; Zhang, Guofan2; Holland, Peter W. H.1
2015-03-01
发表期刊GENOME BIOLOGY AND EVOLUTION
卷号7期号:3页码:677-688
文章类型Article
摘要The metazoan superclade Lophotrochozoa includes mollusks, annelids, and several other animal phyla. It is reasonable to assume that this organismal diversity may be traced, in part, to changes in developmentally important genes, such as the homeobox genes. Although most comparative studies have focussed on ancient homeobox gene families conserved across bilaterians, there are also "novel" homeobox genes that have arisen more recently in evolution, presumably by duplication followed by radical divergence and functional change. We classify 136 homeobox genes in the genome sequence of the Pacific oyster, Crassostrea gigas. The genome shows an unusually low degree of homeobox gene clustering, with disruption of the NK, Hox, and ParaHox gene clusters. Among the oyster genes, 31 do not fall into ancient metazoan or bilaterian homeobox gene families; we deduce that they originated in the lophotrochozoan clade. We compared eight lophotrochozoan genomes to trace the pattern of homeobox gene evolution across this clade, allowing us to define 19 new lophotrochozoan-specific clades within the ANTP, PRD, TALE, ZF, SIX, and CUT classes. Using transcriptome data, we compared temporal expression of each homeobox gene in oyster development, and discovered that the lophotrochozoan-specific homeobox genes have peak expressio neither in early development (egg to gastrula) or in late development (after the trochophore larval stage), but rarely in between. This finding is consistent with the egg-timer, hourglass or phylotypic stage model of developmental evolution, in which there is a conserved central phase of development, but more evolutionarily labile early and late phases.
关键词Gene Duplication Gene Families Annelida Mollusca Platyhelminthes Rotifera Homeodomain
DOI10.1093/gbe/evv018
收录类别SCI
语种英语
WOS记录号WOS:000354750300005
引用统计
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/33036
专题海洋生物技术研发中心
作者单位1.Univ Oxford, Dept Zool, Oxford OX1 2JD, England
2.Chinese Acad Sci, Inst Oceanol, Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao, Peoples R China
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Paps, Jordi,Xu, Fei,Zhang, Guofan,et al. Reinforcing the Egg-Timer: Recruitment of Novel Lophotrochozoa Homeobox Genes to Early and Late Development in the Pacific Oyster[J]. GENOME BIOLOGY AND EVOLUTION,2015,7(3):677-688.
APA Paps, Jordi,Xu, Fei,Zhang, Guofan,&Holland, Peter W. H..(2015).Reinforcing the Egg-Timer: Recruitment of Novel Lophotrochozoa Homeobox Genes to Early and Late Development in the Pacific Oyster.GENOME BIOLOGY AND EVOLUTION,7(3),677-688.
MLA Paps, Jordi,et al."Reinforcing the Egg-Timer: Recruitment of Novel Lophotrochozoa Homeobox Genes to Early and Late Development in the Pacific Oyster".GENOME BIOLOGY AND EVOLUTION 7.3(2015):677-688.
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