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Antithrombotic effects of bromophenol, an alga-derived thrombin inhibitor
Shi Dayong1; Li Xiaohong2; Li Jing1; Guo Shuju1; Su Hua1; Fan Xiao1
2010
发表期刊CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
卷号28期号:1页码:96-98
文章类型Article
摘要Thrombin, the ultimate proteinase of the coagulation cascade, is an attractive target for the treatment of a variety of cardiovascular diseases. A bromophenol derivative named (+)-3-(2,3-dibromo-4, 5-dihydroxy-phenyl)-4-bromo-5,6-dihydroxy-1,3-dihydroiso-benzofuran 1, isolated from the brown alga Leathesia nana exhibited significant thrombin inhibitory activity. In this study, we investigated the inhibition of human thrombin in vitro with this bromophenol derivative, and its antithrombotic efficacy in vivo using the arteriovenous shunt model and the ferric chloride-induced arterial thrombosis model in rats. The results show that the bromophenol derivative is a potential inhibitor of thrombin (IC(50) = 1.03 nmol/L). In antithrombotic experiments in vivo, the bromophenol derivative also shows good effect comparing with the control group. These data indicate that the bromophenol derivative is a potential drug for prophylaxis and the treatment of thrombotic diseases.
关键词Thrombin Inhibitor Antithrombotic Effect Bromophenol Derivative
DOI10.1007/s00343-010-9213-0
收录类别SCI
语种英语
WOS记录号WOS:000275654100013
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/32889
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
2.Qingdao Municipal Hosp, Qingdao 266011, Peoples R China
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GB/T 7714
Shi Dayong,Li Xiaohong,Li Jing,et al. Antithrombotic effects of bromophenol, an alga-derived thrombin inhibitor[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2010,28(1):96-98.
APA Shi Dayong,Li Xiaohong,Li Jing,Guo Shuju,Su Hua,&Fan Xiao.(2010).Antithrombotic effects of bromophenol, an alga-derived thrombin inhibitor.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,28(1),96-98.
MLA Shi Dayong,et al."Antithrombotic effects of bromophenol, an alga-derived thrombin inhibitor".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 28.1(2010):96-98.
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