IOCAS-IR  > 实验海洋生物学重点实验室
Analysis of the vaccine potential of a natural avirulent Edwardsiella tarda isolate
Cheng, Shuang1,2; Hu, Yong-hua1; Zhang, Min1; Sun, Li1
2010-03-24
Source PublicationVACCINE
Volume28Issue:15Pages:2716-2721
SubtypeArticle
AbstractEdwardsiella tarda is a severe aquaculture pathogen that can infect many fish species and cause a systematic disease called edwardsiellosis, which can lead to high mortality under certain conditions. Currently, most vaccine candidates against edwardsiellosis are based on pathogenic E. tarda strains, which can be a concern in some cases. In this study, the vaccine potential of a natural E. tarda isolate, ATCC 15947, was examined in a Japanese flounder model. ATCC 15947 was found to be relatively avirulent to flounder but able to disseminate into and survive transiently in fish tissues following intraperitoneal (i.p.) injection. Fish vaccinated with ATCC 15947 via i.p. injection exhibited a high level of survival rate, which was increased to 100% by a booster injection. Fish vaccinated with ATCC 15947 orally in the form of alginate microspheres showed a moderate survival rate, while fish vaccinated with ATCC 15947 via the immersion route exhibited a low rate of survival. Following oral vaccination, ATCC 15947 could colonize transiently in the gut, liver, and spleen of the vaccinated fish. Both injection and oral vaccination with ATCC 15947 induced production of specific serum antibodies, the levels of which at different time points following vaccination were generally higher in fish vaccinated with ATCC 15947 via injection than in fish vaccinated with ATCC 15947 orally. Compared to control fish, fish vaccinated with ATCC 15947 showed enhanced serum bactericidal activity and significantly increased expression in genes encoding a number of immune-related factors. These results indicated that ATCC 15947 possesses good immunoprotective potential, which may be exploited in the development of E. tarda vaccines. (C) 2010 Elsevier Ltd. All rights reserved.
KeywordAtcc 15947 Edwardsiella Tarda Vaccine
DOI10.1016/j.vaccine.2010.01.023
Indexed BySCI
Language英语
WOS IDWOS:000276174600005
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/32856
Collection实验海洋生物学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Cheng, Shuang,Hu, Yong-hua,Zhang, Min,et al. Analysis of the vaccine potential of a natural avirulent Edwardsiella tarda isolate[J]. VACCINE,2010,28(15):2716-2721.
APA Cheng, Shuang,Hu, Yong-hua,Zhang, Min,&Sun, Li.(2010).Analysis of the vaccine potential of a natural avirulent Edwardsiella tarda isolate.VACCINE,28(15),2716-2721.
MLA Cheng, Shuang,et al."Analysis of the vaccine potential of a natural avirulent Edwardsiella tarda isolate".VACCINE 28.15(2010):2716-2721.
Files in This Item:
File Name/Size DocType Version Access License
Analysis of the vacc(336KB)期刊论文出版稿开放获取ODC PDDLView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Cheng, Shuang]'s Articles
[Hu, Yong-hua]'s Articles
[Zhang, Min]'s Articles
Baidu academic
Similar articles in Baidu academic
[Cheng, Shuang]'s Articles
[Hu, Yong-hua]'s Articles
[Zhang, Min]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Cheng, Shuang]'s Articles
[Hu, Yong-hua]'s Articles
[Zhang, Min]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Analysis of the vaccine potential of a natural avirulent Edwardsiella tarda isolate.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.