Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| 7-Nor-ergosterolide, a Pentalactone-Containing Norsteroid and Related Steroids from the Marine-Derived Endophytic Aspergillus ochraceus EN-31 | |
Cui, Chuan-Ming1,3; Li, Xiao-Ming1; Meng, Li2; Li, Chun-Shun1; Huang, Cai-Guo2; Wang, Bin-Gui1
| |
| 2010-11-01 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
 |
| 卷号 | 73期号:11页码:1780-1784 |
| 文章类型 | Article |
| 摘要 | 7-Nor-ergosterolide (1), a rare 7-norsteroid with an unusual pentalactone B-ring system, and two new steroid derivatives, 3 beta,11 alpha-dihydroxyergosta-8,24(28)-dien-7-one (2) and 3 beta-hydroxyergosta-8,24(28)-dien-7-one (3), were characterized from the culture extract of Aspergillus ochraceus EN-31, an endophytic fungus isolated from the marine brown alga Sargassum kjellmanianum. In addition, nine known related steroids were isolated and identified. The structures of these compounds were established on the basis of extensive spectroscopic analysis. The absolute configuration of the new steroids (1-3) was determined by application of the modified Mosher's method. Compound 1, which represents the first example of a 7-nor-ergosteroid possessing a pentalactone B-ring system in a naturally occurring steroid, displayed cytotoxicity against NCl-H460, SMMC-7721, and SW1990 cell lines with IC50 values of 5.0, 7.0, and 28.0 mu g/mL, respectively. Compound 2 also displayed cytotoxicity against the SMMC-7721 cell line with an IC50 value of 28.0 mu g/mL. |
| DOI | 10.1021/np100386q |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000284559100007 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/32766 |
| 专题 | 实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Second Mil Med Univ, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 第一作者单位 | 实验海洋生物学重点实验室 |
| 推荐引用方式 GB/T 7714 | Cui, Chuan-Ming,Li, Xiao-Ming,Meng, Li,et al. 7-Nor-ergosterolide, a Pentalactone-Containing Norsteroid and Related Steroids from the Marine-Derived Endophytic Aspergillus ochraceus EN-31[J]. JOURNAL OF NATURAL PRODUCTS,2010,73(11):1780-1784. |
| APA | Cui, Chuan-Ming,Li, Xiao-Ming,Meng, Li,Li, Chun-Shun,Huang, Cai-Guo,&Wang, Bin-Gui.(2010).7-Nor-ergosterolide, a Pentalactone-Containing Norsteroid and Related Steroids from the Marine-Derived Endophytic Aspergillus ochraceus EN-31.JOURNAL OF NATURAL PRODUCTS,73(11),1780-1784. |
| MLA | Cui, Chuan-Ming,et al."7-Nor-ergosterolide, a Pentalactone-Containing Norsteroid and Related Steroids from the Marine-Derived Endophytic Aspergillus ochraceus EN-31".JOURNAL OF NATURAL PRODUCTS 73.11(2010):1780-1784. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| 7-Nor-ergosterolide,（666KB） | 期刊论文 | 出版稿 | 限制开放 | ODC PDDL | 浏览 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论