Toxicology mechanism of the persistent organic pollutants (POPs) in fish through AhR pathway

doi:10.3109/15376516.2010.485227

IOCAS-IR > 实验海洋生物学重点实验室

	Toxicology mechanism of the persistent organic pollutants (POPs) in fish through AhR pathway
	Zhou, Hailong 1,2,3,4; Wu, Huifeng 1; Liao, Chunyang 1; Diao, Xiaoping 2; Zhen, Jiping 2; Chen, Linlin 1; Xue, Qinzhao 1
	2010-07-01
发表期刊	TOXICOLOGY MECHANISMS AND METHODS
卷号	20 期号:6 页码:279-286
文章类型	Review
摘要	With the development of industry and agriculture, the cases of cancer and tumor have been increasing gradually in the last 30 years, and quite a few cases are caused by persistent organic pollutants (POPs), some of them belonging to environmental endocrine disruptors, and they have become ubiquitous in the environment, especially in the aquatic ecosystem; so this issue has aroused the extensive attention of the world. The mechanism of POPs toxicology is very complicated, but it is mainly mediated by the aryl hydrocarbon receptor (AhR) pathway in fish. In order to gain a comprehensive understanding of the AhR pathway, the present paper focuses on reviewing it from four major steps, including formation of cytosolic complex, translocation of AhR, heterodimerization of AhR, and induction of CYP1A. This study summarized the isoform numbers of AhR pathway genes and the expression patterns in the regulation process of POPs toxicology in zebrafish.
关键词	Persistent Organic Pollutants Ahr Pathway Toxicology Mechanism Fish
DOI	10.3109/15376516.2010.485227
收录类别	SCI
语种	英语
WOS记录号	WOS:000280402000001
引用统计	被引频次：50[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/32756
专题	实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Hainan Univ, Dept Biotechnol, Coll Agr, Haikou 570228, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Zhou, Hailong,Wu, Huifeng,Liao, Chunyang,et al. Toxicology mechanism of the persistent organic pollutants (POPs) in fish through AhR pathway[J]. TOXICOLOGY MECHANISMS AND METHODS,2010,20(6):279-286.
APA	Zhou, Hailong.,Wu, Huifeng.,Liao, Chunyang.,Diao, Xiaoping.,Zhen, Jiping.,...&Xue, Qinzhao.(2010).Toxicology mechanism of the persistent organic pollutants (POPs) in fish through AhR pathway.TOXICOLOGY MECHANISMS AND METHODS,20(6),279-286.
MLA	Zhou, Hailong,et al."Toxicology mechanism of the persistent organic pollutants (POPs) in fish through AhR pathway".TOXICOLOGY MECHANISMS AND METHODS 20.6(2010):279-286.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Toxicology mechanism（875KB）	期刊论文	出版稿	限制开放	ODC PDDL	浏览