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Preparation, structural characterization and in vitro antitumor activity of kappa-carrageenan oligosaccharide fraction from Kappaphycus striatum | |
Yuan, HM; Song, JM | |
2005 | |
发表期刊 | JOURNAL OF APPLIED PHYCOLOGY |
ISSN | 0921-8971 |
卷号 | 17期号:1页码:7-13 |
文章类型 | Article |
摘要 | Oligosaccharides were prepared through mild hydrochloric acid hydrolysis of kappa-carrageenan from Kappaphycus striatum to compare the antitumor activity with carrageenan polysaccharides. Oligosaccharide fractions were isolated by gel permeation chromatography and the structure of fraction 1 (F1) was studied by using negative- ion electrospray ionization-mass spectrometry (ESI-MS), and H-1 and C-13-NMR spectrometry. The in vitro antitumor effects in three human neoplastic cell lines (KB, BGC, and Hela) of polysaccharides and F1 were investigated. The bioassay results showed that F1 exhibited relatively higher antitumor activity against the three cancer cells than polysaccharides.; Oligosaccharides were prepared through mild hydrochloric acid hydrolysis of kappa-carrageenan from Kappaphycus striatum to compare the antitumor activity with carrageenan polysaccharides. Oligosaccharide fractions were isolated by gel permeation chromatography and the structure of fraction 1 (F1) was studied by using negative- ion electrospray ionization-mass spectrometry (ESI-MS), and H-1 and C-13-NMR spectrometry. The in vitro antitumor effects in three human neoplastic cell lines (KB, BGC, and Hela) of polysaccharides and F1 were investigated. The bioassay results showed that F1 exhibited relatively higher antitumor activity against the three cancer cells than polysaccharides. |
关键词 | Kappa-carrageenan Kappaphycus Striatum Oligosaccharides Antitumor |
学科领域 | Biotechnology & Applied Microbiology ; Marine & Freshwater Biology |
DOI | 10.1007/s10811-005-5513-8 |
URL | 查看原文 |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000229904700002 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.qdio.ac.cn/handle/337002/2706 |
专题 | 海洋生态与环境科学重点实验室 海洋地质与环境重点实验室 |
作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
推荐引用方式 GB/T 7714 | Yuan, HM,Song, JM. Preparation, structural characterization and in vitro antitumor activity of kappa-carrageenan oligosaccharide fraction from Kappaphycus striatum[J]. JOURNAL OF APPLIED PHYCOLOGY,2005,17(1):7-13. |
APA | Yuan, HM,&Song, JM.(2005).Preparation, structural characterization and in vitro antitumor activity of kappa-carrageenan oligosaccharide fraction from Kappaphycus striatum.JOURNAL OF APPLIED PHYCOLOGY,17(1),7-13. |
MLA | Yuan, HM,et al."Preparation, structural characterization and in vitro antitumor activity of kappa-carrageenan oligosaccharide fraction from Kappaphycus striatum".JOURNAL OF APPLIED PHYCOLOGY 17.1(2005):7-13. |
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