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Preparation and in vitro antioxidant activity of kappa-carrageenan oligosaccharides and their oversulfated, acetylated, and phosphorylated derivatives
Yuan, HM; Zhang, WW; Li, XG; Lu, XX; Li, N; Gao, XL; Song, JM
2005-03-21
Source PublicationCARBOHYDRATE RESEARCH
ISSN0008-6215
Volume340Issue:4Pages:685-692
SubtypeArticle
AbstractIn order to study the relationship between chemical structure and properties of modified carrageenans versus antioxidant activity in vitro, K-carrageenan oligosaccharides were prepared through mild hydrochloric acid hydrolysis of the polysaccharide, and these were used as starting materials for the partial synthesis of their oversulfated, acetylated, and phosphorylated derivatives. The structure and substitution pattern of the oligosaccharides and their derivatives were Studied using FTIR and C-13 NMR spectroscopy, and their in vitro antioxidant activities were investigated. Certain derivatives of the carrageenan oligosaccharides exhibited higher antioxidant activity than the polysaccharides and oligosaccharides in certain antioxidant systems. The oversulfated and acetylated derivatives, which scavenge superoxide radicals, the phosphorylated and low-DS acetylated derivatives, which scavenge hydroxyl radicals, and the phosphorylated derivatives, which scavenge DPPH radicals, all exhibited significant antioxidant activities it, the systems examined. The effect of the molecular weight of the carrageenan on antioxidant activities, however, is not obvious from these studies. (c) 2005 Elsevier Ltd. All rights reserved.; In order to study the relationship between chemical structure and properties of modified carrageenans versus antioxidant activity in vitro, K-carrageenan oligosaccharides were prepared through mild hydrochloric acid hydrolysis of the polysaccharide, and these were used as starting materials for the partial synthesis of their oversulfated, acetylated, and phosphorylated derivatives. The structure and substitution pattern of the oligosaccharides and their derivatives were Studied using FTIR and C-13 NMR spectroscopy, and their in vitro antioxidant activities were investigated. Certain derivatives of the carrageenan oligosaccharides exhibited higher antioxidant activity than the polysaccharides and oligosaccharides in certain antioxidant systems. The oversulfated and acetylated derivatives, which scavenge superoxide radicals, the phosphorylated and low-DS acetylated derivatives, which scavenge hydroxyl radicals, and the phosphorylated derivatives, which scavenge DPPH radicals, all exhibited significant antioxidant activities it, the systems examined. The effect of the molecular weight of the carrageenan on antioxidant activities, however, is not obvious from these studies. (c) 2005 Elsevier Ltd. All rights reserved.
KeywordCarrageenan Oligosaccharide Oversulfated Acetylated Phosphorylated Antioxidant Activity In Vitro
Subject AreaBiochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic
DOI10.1016/j.carres.2004.12.026
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000227691300020
Citation statistics
Cited Times:234[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/2704
Collection海洋生态与环境科学重点实验室
海洋地质与环境重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Ocean Univ China, Marine Geol Coll, Qingdao 266003, Peoples R China
Recommended Citation
GB/T 7714
Yuan, HM,Zhang, WW,Li, XG,et al. Preparation and in vitro antioxidant activity of kappa-carrageenan oligosaccharides and their oversulfated, acetylated, and phosphorylated derivatives[J]. CARBOHYDRATE RESEARCH,2005,340(4):685-692.
APA Yuan, HM.,Zhang, WW.,Li, XG.,Lu, XX.,Li, N.,...&Song, JM.(2005).Preparation and in vitro antioxidant activity of kappa-carrageenan oligosaccharides and their oversulfated, acetylated, and phosphorylated derivatives.CARBOHYDRATE RESEARCH,340(4),685-692.
MLA Yuan, HM,et al."Preparation and in vitro antioxidant activity of kappa-carrageenan oligosaccharides and their oversulfated, acetylated, and phosphorylated derivatives".CARBOHYDRATE RESEARCH 340.4(2005):685-692.
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