Preparation and in vitro antioxidant activity of kappa-carrageenan oligosaccharides and their oversulfated, acetylated, and phosphorylated derivatives

doi:10.1016/j.carres.2004.12.026

	Preparation and in vitro antioxidant activity of kappa-carrageenan oligosaccharides and their oversulfated, acetylated, and phosphorylated derivatives
	Yuan, HM; Zhang, WW ; Li, XG ; Lu, XX ; Li, N ; Gao, XL; Song, JM
	2005-03-21
发表期刊	CARBOHYDRATE RESEARCH
ISSN	0008-6215
卷号	340 期号:4 页码:685-692
文章类型	Article
摘要	In order to study the relationship between chemical structure and properties of modified carrageenans versus antioxidant activity in vitro, K-carrageenan oligosaccharides were prepared through mild hydrochloric acid hydrolysis of the polysaccharide, and these were used as starting materials for the partial synthesis of their oversulfated, acetylated, and phosphorylated derivatives. The structure and substitution pattern of the oligosaccharides and their derivatives were Studied using FTIR and C-13 NMR spectroscopy, and their in vitro antioxidant activities were investigated. Certain derivatives of the carrageenan oligosaccharides exhibited higher antioxidant activity than the polysaccharides and oligosaccharides in certain antioxidant systems. The oversulfated and acetylated derivatives, which scavenge superoxide radicals, the phosphorylated and low-DS acetylated derivatives, which scavenge hydroxyl radicals, and the phosphorylated derivatives, which scavenge DPPH radicals, all exhibited significant antioxidant activities it, the systems examined. The effect of the molecular weight of the carrageenan on antioxidant activities, however, is not obvious from these studies. (c) 2005 Elsevier Ltd. All rights reserved.; In order to study the relationship between chemical structure and properties of modified carrageenans versus antioxidant activity in vitro, K-carrageenan oligosaccharides were prepared through mild hydrochloric acid hydrolysis of the polysaccharide, and these were used as starting materials for the partial synthesis of their oversulfated, acetylated, and phosphorylated derivatives. The structure and substitution pattern of the oligosaccharides and their derivatives were Studied using FTIR and C-13 NMR spectroscopy, and their in vitro antioxidant activities were investigated. Certain derivatives of the carrageenan oligosaccharides exhibited higher antioxidant activity than the polysaccharides and oligosaccharides in certain antioxidant systems. The oversulfated and acetylated derivatives, which scavenge superoxide radicals, the phosphorylated and low-DS acetylated derivatives, which scavenge hydroxyl radicals, and the phosphorylated derivatives, which scavenge DPPH radicals, all exhibited significant antioxidant activities it, the systems examined. The effect of the molecular weight of the carrageenan on antioxidant activities, however, is not obvious from these studies. (c) 2005 Elsevier Ltd. All rights reserved.
关键词	Carrageenan Oligosaccharide Oversulfated Acetylated Phosphorylated Antioxidant Activity In Vitro
学科领域	Biochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic
DOI	10.1016/j.carres.2004.12.026
URL	查看原文
收录类别	SCI
语种	英语
WOS记录号	WOS:000227691300020
引用统计	被引频次：240[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/2704
专题	海洋生态与环境科学重点实验室海洋地质与环境重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Ocean Univ China, Marine Geol Coll, Qingdao 266003, Peoples R China
推荐引用方式 GB/T 7714	Yuan, HM,Zhang, WW,Li, XG,et al. Preparation and in vitro antioxidant activity of kappa-carrageenan oligosaccharides and their oversulfated, acetylated, and phosphorylated derivatives[J]. CARBOHYDRATE RESEARCH,2005,340(4):685-692.
APA	Yuan, HM.,Zhang, WW.,Li, XG.,Lu, XX.,Li, N.,...&Song, JM.(2005).Preparation and in vitro antioxidant activity of kappa-carrageenan oligosaccharides and their oversulfated, acetylated, and phosphorylated derivatives.CARBOHYDRATE RESEARCH,340(4),685-692.
MLA	Yuan, HM,et al."Preparation and in vitro antioxidant activity of kappa-carrageenan oligosaccharides and their oversulfated, acetylated, and phosphorylated derivatives".CARBOHYDRATE RESEARCH 340.4(2005):685-692.

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