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Highly diverse fibrinogen-related proteins in the Pacific oyster Crassostrea gigas
Huang, Baoyu1,2; Zhang, Linlin1; Li, Li1; Tang, Xueying1,2; Zhang, Guofan1
2015-04-01
发表期刊FISH & SHELLFISH IMMUNOLOGY
卷号43期号:2页码:485-490
文章类型Article
摘要Fibrinogen-related proteins (FREPs) are a family of proteins with high sequence diversity, and they play crucial roles in invertebrate immune response. However, few studies have characterized this diversity at the whole-genome level. In the present study, approximately 190 predicted FREPs with more than 200 fibrinogen-like (FBG) domains were identified in the genome of the Pacific oyster (Crassostrea gigas), suggesting a historical expansion of this protein family. A sequence analysis showed high numbers of polymorphisms in C. gigas FREP (CgFREP) genes, which may contribute to the versatile immune function of FREPs. A phylogenetic analysis of molluscan FREP sequences indicated lineage-specific duplication of these genes in C. gigas. Additionally, several CgFREP mRNAs were highly expressed in the gills, digestive glands, and hemocytes. Taken together, these findings will help elucidate FREP immune function and facilitate studies of the functional validation of this gene family. (C) 2015 Elsevier Ltd. All rights reserved.
关键词Crassostrea Gigas Frep Innate Immune Genome Expansion Sequence Diversity
DOI10.1016/j.fsi.2015.01.021
收录类别SCI
语种英语
WOS记录号WOS:000352923700021
引用统计
被引频次:30[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/25478
专题海洋生物技术研发中心
作者单位1.Chinese Acad Sci, Inst Oceanol, Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位中国科学院海洋研究所
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Huang, Baoyu,Zhang, Linlin,Li, Li,et al. Highly diverse fibrinogen-related proteins in the Pacific oyster Crassostrea gigas[J]. FISH & SHELLFISH IMMUNOLOGY,2015,43(2):485-490.
APA Huang, Baoyu,Zhang, Linlin,Li, Li,Tang, Xueying,&Zhang, Guofan.(2015).Highly diverse fibrinogen-related proteins in the Pacific oyster Crassostrea gigas.FISH & SHELLFISH IMMUNOLOGY,43(2),485-490.
MLA Huang, Baoyu,et al."Highly diverse fibrinogen-related proteins in the Pacific oyster Crassostrea gigas".FISH & SHELLFISH IMMUNOLOGY 43.2(2015):485-490.
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