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CsCTL1, a teleost C-type lectin that promotes antibacterial and antiviral immune defense in a manner that depends on the conserved EPN motif
Zhou, Ze-jun1,2; Sun, Li1
2015-06-01
Source PublicationDEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
Volume50Issue:2Pages:69-77
SubtypeArticle
AbstractMany C-type lectins (CTLs) have been identified in teleost, however, the in vivo function of fish Cas is essentially unknown. In this study, we examined the function of a CTL (CsCTL1) from tongue sole. CsCTL1 possesses the conserved EPN motif required for mannose binding in mammals but unknown in function in fish. Recombinant CsCTL1 (rCsCTL1), but not the mutant rCsCTL1M bearing substitutions at EPN, interacted with and agglutinated a limited range of bacteria. The agglutinating ability of rCsCTL1 was abolished in the absence of calcium or presence of mannose. Binding of rCsCTL1 to bacteria promoted phagocytosis and antimicrobial activity of head kidney monocytes. Fish administered with rCsCTL1 exhibited enhanced resistance against bacterial and viral infections. These results provide the first evidence that the EPN site is essential to a fish CTL and that, in addition to antibacterial properties, a fish CTL promotes the immune defense against viral infection as well. (C) 2015 Elsevier Ltd. All rights reserved.
KeywordC-type Lectin Cynoglossus Semilaevis Immune Effect Antibacterial Antiviral
DOI10.1016/j.dci.2015.01.007
Indexed BySCI
Language英语
WOS IDWOS:000353010700001
Citation statistics
Cited Times:42[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/25477
Collection实验海洋生物学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
First Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhou, Ze-jun,Sun, Li. CsCTL1, a teleost C-type lectin that promotes antibacterial and antiviral immune defense in a manner that depends on the conserved EPN motif[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2015,50(2):69-77.
APA Zhou, Ze-jun,&Sun, Li.(2015).CsCTL1, a teleost C-type lectin that promotes antibacterial and antiviral immune defense in a manner that depends on the conserved EPN motif.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,50(2),69-77.
MLA Zhou, Ze-jun,et al."CsCTL1, a teleost C-type lectin that promotes antibacterial and antiviral immune defense in a manner that depends on the conserved EPN motif".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 50.2(2015):69-77.
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