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| CsCTL1, a teleost C-type lectin that promotes antibacterial and antiviral immune defense in a manner that depends on the conserved EPN motif | |
Zhou, Ze-jun1,2 ; Sun, Li1
| |
| 2015-06-01 | |
| 发表期刊 | DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
 |
| 卷号 | 50期号:2页码:69-77 |
| 文章类型 | Article |
| 摘要 | Many C-type lectins (CTLs) have been identified in teleost, however, the in vivo function of fish Cas is essentially unknown. In this study, we examined the function of a CTL (CsCTL1) from tongue sole. CsCTL1 possesses the conserved EPN motif required for mannose binding in mammals but unknown in function in fish. Recombinant CsCTL1 (rCsCTL1), but not the mutant rCsCTL1M bearing substitutions at EPN, interacted with and agglutinated a limited range of bacteria. The agglutinating ability of rCsCTL1 was abolished in the absence of calcium or presence of mannose. Binding of rCsCTL1 to bacteria promoted phagocytosis and antimicrobial activity of head kidney monocytes. Fish administered with rCsCTL1 exhibited enhanced resistance against bacterial and viral infections. These results provide the first evidence that the EPN site is essential to a fish CTL and that, in addition to antibacterial properties, a fish CTL promotes the immune defense against viral infection as well. (C) 2015 Elsevier Ltd. All rights reserved. |
| 关键词 | C-type Lectin Cynoglossus Semilaevis Immune Effect Antibacterial Antiviral |
| DOI | 10.1016/j.dci.2015.01.007 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000353010700001 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/25477 |
| 专题 | 实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 第一作者单位 | 实验海洋生物学重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhou, Ze-jun,Sun, Li. CsCTL1, a teleost C-type lectin that promotes antibacterial and antiviral immune defense in a manner that depends on the conserved EPN motif[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2015,50(2):69-77. |
| APA | Zhou, Ze-jun,&Sun, Li.(2015).CsCTL1, a teleost C-type lectin that promotes antibacterial and antiviral immune defense in a manner that depends on the conserved EPN motif.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,50(2),69-77. |
| MLA | Zhou, Ze-jun,et al."CsCTL1, a teleost C-type lectin that promotes antibacterial and antiviral immune defense in a manner that depends on the conserved EPN motif".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 50.2(2015):69-77. |
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