Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| New butenolide derivatives from the marine-derived fungus Paecilomyces variotii with DPPH radical scavenging activity | |
Zhang, Peng1,2 ; Li, Xiao-Ming1; Wang, Jia-Ning1,2; Li, Xin1,2; Wang, Bin-Gui1
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| 2015-03-01 | |
| 发表期刊 | PHYTOCHEMISTRY LETTERS
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| 卷号 | 11页码:85-88 |
| 文章类型 | Article |
| 摘要 | Bioassay-guided fractionation of the marine-derived endophytic fungus Paecilomyces variotii resulted in the isolation of two new butenolides, namely, butyrolactone IX (1) and aspulvinone O (7), together with eight known related congeners, butyrolactones I, IV, V, and VI (2-5), aspernolide A (6), and aspulvinones H, C, and D (8-10). Their structures were elucidated on the basis of detailed spectroscopic analysis and by comparison with literature data. All of the isolated butenolides were tested for their activity against DPPH radicals and the results showed that butyrolactones (1-6) possessed potent activity with IC50 values ranging from 38.0 to 186.3 mu M, while aspulvinones (7-10) exhibited significant activities with IC50 values ranging from 11.6 to 29.4 mu M, which are stronger than that of the positive control BHT (with IC50 117.7 mu M). The preliminary structure-activity relationship was discussed. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved. |
| 关键词 | Marine Algal-derived Fungus Paecilomyces Variotii Butenolide Dpph Radical Scavenging Activity |
| DOI | 10.1016/j.phytol.2014.11.014 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000350569100017 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/25426 |
| 专题 | 实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 第一作者单位 | 实验海洋生物学重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhang, Peng,Li, Xiao-Ming,Wang, Jia-Ning,et al. New butenolide derivatives from the marine-derived fungus Paecilomyces variotii with DPPH radical scavenging activity[J]. PHYTOCHEMISTRY LETTERS,2015,11:85-88. |
| APA | Zhang, Peng,Li, Xiao-Ming,Wang, Jia-Ning,Li, Xin,&Wang, Bin-Gui.(2015).New butenolide derivatives from the marine-derived fungus Paecilomyces variotii with DPPH radical scavenging activity.PHYTOCHEMISTRY LETTERS,11,85-88. |
| MLA | Zhang, Peng,et al."New butenolide derivatives from the marine-derived fungus Paecilomyces variotii with DPPH radical scavenging activity".PHYTOCHEMISTRY LETTERS 11(2015):85-88. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| New butenolide deriv（345KB） | 期刊论文 | 出版稿 | 限制开放 | ODC PDDL | 浏览 | |
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