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Immune response and gene expression in hemocytes of Portunus trituberculatus inoculated with the parasitic dinoflagellate Hematodinium
Li, Meng1,2; Li, Caiwen1; Wang, Jinfeng1,2; Song, Shuqun1
2015-05-01
发表期刊MOLECULAR IMMUNOLOGY
卷号65期号:1页码:113-122
文章类型Article
摘要The parasitic dinoflagellates in the genus of Hematodinium infect broad range of crustaceans around the world, causing fatal diseases in multiple species of wild and cultured crabs and subsequent economic loss. In order to explore this host parasite interaction in the early development stage of infection, mRNA transcript levels of eight key immune-related genes, including LGBP, proPO, PPAF, serpin, alpha 2m, and three PTcSPs were quantitatively assessed in Portunus trituberculatus artificially inoculated with the Hematodinium parasites. The fluctuation of proPO gene expression indicated that the host proPO system was disturbed overtly due to the intrusion of the parasites. And as manifested by the suppressed expression of LGBP and PPAF, an immunosuppressive mechanism was likely induced by the parasites against being entrapped or killed by the host proPO system. Furthermore, the significant variations of the transcript levels of serpin, alpha 2m, and the three PTcSPs suggested that the parasites affected the proteinase cascade reactions associated with the immune response by destroying the balance between serine proteinases and the proteinase inhibitors. The hemocytes counts and PO activity varied accordingly over the time course of infection, showing that hemocytes were actively involved in the immune response against the parasitic invasion. This study primarily highlighted the anti-parasitic immune response of crab hosts, and presented the first report of the immune response of P. trituberculatus to the parasitic dinoflagellate Hematodinium. (C) 2015 Elsevier Ltd. All rights reserved.
关键词Portunus Trituberculatus Parasites Host Parasite Interaction Innate Immunity Gene Expression
DOI10.1016/j.molimm.2015.01.002
收录类别SCI
语种英语
WOS记录号WOS:000350839500013
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/25413
专题海洋生态与环境科学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位中国科学院海洋研究所
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Li, Meng,Li, Caiwen,Wang, Jinfeng,et al. Immune response and gene expression in hemocytes of Portunus trituberculatus inoculated with the parasitic dinoflagellate Hematodinium[J]. MOLECULAR IMMUNOLOGY,2015,65(1):113-122.
APA Li, Meng,Li, Caiwen,Wang, Jinfeng,&Song, Shuqun.(2015).Immune response and gene expression in hemocytes of Portunus trituberculatus inoculated with the parasitic dinoflagellate Hematodinium.MOLECULAR IMMUNOLOGY,65(1),113-122.
MLA Li, Meng,et al."Immune response and gene expression in hemocytes of Portunus trituberculatus inoculated with the parasitic dinoflagellate Hematodinium".MOLECULAR IMMUNOLOGY 65.1(2015):113-122.
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