| Synthesis and antifungal properties of (4-tolyloxy)-pyrimidyl-alpha-aminophosphonates chitosan derivatives | |
Qin, Yukun1; Xing, Ronge1 ; Liu, Song1; Yu, Huahua1; Li, Kecheng1; Hu, Linfeng1,2; Li, Pengcheng1; Li, PC (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China.
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| 2014-02-01 | |
| 发表期刊 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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| 卷号 | 63页码:83-91 |
| 文章类型 | Article |
| 摘要 | A novel class of alpha-aminophosphonate chitosan derivatives was investigated. These chitosan derivatives consist of (4-tolyloxy)-pyrimidyl-dimethyl-alpha-amino-phosphonate chitosan (alpha-ATPMCS) and (4-tolyloxy)-pyrimidyl-diethyl-alpha-aminophosphonate chitosan (alpha-ATPECS). Their structures were well defined. Antifungal activity of them against some crop-threatening pathogenic fungi was tested in vitro. The derivatives were found to have a broad-spectrum antifungal activity that was obviously enhanced compared with chitosan. At 250 mg/L, both alpha-ATPMCS and alpha-ATPECS even inhibited growth of Phomopsis asparagi (Sacc.) (P. asparagi) and Fusarium oxysporum (F. oxysporum) at 100%, which was even stronger than polyoxin whose antifungal index was 37.2% and 32.1%, respectively. Additionally, the initial mechanism of the chitosan derivatives in F. oxysporum model was studied. It was found that the derivatives may have an effect on membrane permeability of the fungi. The results demonstrated the derivatives may serve as attractive candidates in crop protection. (C) 2013 Elsevier B.V. All rights reserved. |
| 关键词 | Alpha-aminophosphonate Chitosan Synthesis Antifungal Activity |
| 学科领域 | Biochemistry & Molecular Biology |
| DOI | 10.1016/j.ijbiomac.2013.10.023 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000330603800012 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/24243 |
| 专题 | 海洋生物技术研发中心 海洋环境工程技术研究发展中心 |
| 通讯作者 | Li, PC (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China. |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Henan Inst Sci & Technol, Sch Chem & Chem Engn, Xinxiang 453003, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Qin, Yukun,Xing, Ronge,Liu, Song,et al. Synthesis and antifungal properties of (4-tolyloxy)-pyrimidyl-alpha-aminophosphonates chitosan derivatives[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2014,63:83-91. |
| APA | Qin, Yukun.,Xing, Ronge.,Liu, Song.,Yu, Huahua.,Li, Kecheng.,...&Li, PC .(2014).Synthesis and antifungal properties of (4-tolyloxy)-pyrimidyl-alpha-aminophosphonates chitosan derivatives.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,63,83-91. |
| MLA | Qin, Yukun,et al."Synthesis and antifungal properties of (4-tolyloxy)-pyrimidyl-alpha-aminophosphonates chitosan derivatives".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 63(2014):83-91. |
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