Size and pH effects of chitooligomers on antibacterial activity against Staphylococcus aureus

doi:10.1016/j.ijbiomac.2013.11.037

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	Size and pH effects of chitooligomers on antibacterial activity against Staphylococcus aureus
	Li, Kecheng; Xing, Ronge; Liu, Song; Qin, Yukun; Yu, Huahua; Li, Pengcheng; Li, PC (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China.
	2014-03-01
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷号	64 页码:302-305
文章类型	Article
摘要	The antimicrobial activity of chitooligomers (COSs) has attracted considerable interest but there are few reports on antibacterial activity of each individual COS. This study focuses on investigating the size and pH effects of COS on its antibacterial activity against Staphylococcus aureus. Minimum inhibitory concentrations (MICs) of five single COSs and five COS fractions with narrow degrees of polymerization (DP) were determined at different pH mediums. The results revealed that the antibacterial activity of COS required structural essential with a DP of at least 5 and the inhibitory effect increased with increasing DP. Lower pH value could enhance the antibacterial activity of COS. The COS with DP > 12 showed a MIC value of 62.5 mg/mL at pH 6.0, while the MIC value increased to 500 and 1000 mg/mL at pH 6.5 and 7.0, respectively. The cell membrane integrity assay and SEM suggested that the COS with high DP could cause bacteria clustering and further lysis of cell. (C) 2013 Elsevier B.V. All rights reserved.
关键词	Chitooligomers Size Antibacterial Activity
学科领域	Biochemistry & Molecular Biology
DOI	10.1016/j.ijbiomac.2013.11.037
收录类别	SCI
语种	英语
WOS记录号	WOS:000334147300045
引用统计	被引频次：41[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/24242
专题	海洋生物技术研发中心海洋环境工程技术研究发展中心
通讯作者	Li, PC (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China.
作者单位	Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Li, Kecheng,Xing, Ronge,Liu, Song,et al. Size and pH effects of chitooligomers on antibacterial activity against Staphylococcus aureus[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2014,64:302-305.
APA	Li, Kecheng.,Xing, Ronge.,Liu, Song.,Qin, Yukun.,Yu, Huahua.,...&Li, PC .(2014).Size and pH effects of chitooligomers on antibacterial activity against Staphylococcus aureus.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,64,302-305.
MLA	Li, Kecheng,et al."Size and pH effects of chitooligomers on antibacterial activity against Staphylococcus aureus".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 64(2014):302-305.

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