| CS5931, a Novel Polypeptide in Ciona savignyi, Represses Angiogenesis via Inhibiting Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinases (MMPs) | |
| Liu, Ge1,2; Liu, Ming3; Wei, Jianteng4; Huang, Haijuan5; Zhang, Yuyan5; Zhao, Jin6; Xiao, Lin7; Wu, Ning1; Zheng, Lanhong8; Lin, Xiukun9; Liu, M (reprint author), Ocean Univ China, Sch Med & Pharm, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China. | |
| 2014-03-01 | |
| 发表期刊 | MARINE DRUGS
 |
| 卷号 | 12期号:3页码:1530-1544 |
| 文章类型 | Article |
| 摘要 | CS5931 is a novel polypeptide from Ciona savignyi with anticancer activities. Previous study in our laboratory has shown that CS5931 can induce cell death via mitochondrial apoptotic pathway. In the present study, we found that the polypeptide could inhibit angiogenesis both in vitro and in vivo. CS5931 inhibited the proliferation, migration and formation of capillary-like structures of HUVECs (Human Umbilical Vein Endothelial Cell) in a dose-dependent manner. Additionally, CS5931 repressed spontaneous angiogenesis of the zebrafish vessels. Further studies showed that CS5931 also blocked vascular endothelial growth factor (VEGF) production but without any effect on its mRNA expression. Moreover, CS5931 reduced the expression of matrix metalloproteinases (MMP-2 and MMP-9) both on protein and mRNA levels in HUVEC cells. We demonstrated that CS5931 possessed strong anti-angiogenic activity both in vitro and in vivo, possible via VEGF and MMPs. This study indicates that CS5931 has the potential to be developed as a novel therapeutic agent as an inhibitor of angiogenesis for the treatment of cancer. |
| 关键词 | Zebrafish Anti-angiogenesis Huvecs Cs5931 Vegf And Mmps |
| 学科领域 | Pharmacology & Pharmacy |
| DOI | 10.3390/md12031530 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000335752800023 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/24203 |
| 专题 | 海洋生物技术研发中心 |
| 通讯作者 | Liu, M (reprint author), Ocean Univ China, Sch Med & Pharm, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China. |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Ocean Univ China, Sch Med & Pharm, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China 4.Chinese Acad Sci, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China 5.Qingdao Univ Sci & Technol, Qingdao 266042, Peoples R China 6.Zhengzhou Univ, Dept Biotechnol, Zhengzhou 450001, Peoples R China 7.Qingdao Agr Univ, Qingdao 266109, Peoples R China 8.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China 9.Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Liu, Ge,Liu, Ming,Wei, Jianteng,et al. CS5931, a Novel Polypeptide in Ciona savignyi, Represses Angiogenesis via Inhibiting Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinases (MMPs)[J]. MARINE DRUGS,2014,12(3):1530-1544. |
| APA | Liu, Ge.,Liu, Ming.,Wei, Jianteng.,Huang, Haijuan.,Zhang, Yuyan.,...&Liu, M .(2014).CS5931, a Novel Polypeptide in Ciona savignyi, Represses Angiogenesis via Inhibiting Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinases (MMPs).MARINE DRUGS,12(3),1530-1544. |
| MLA | Liu, Ge,et al."CS5931, a Novel Polypeptide in Ciona savignyi, Represses Angiogenesis via Inhibiting Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinases (MMPs)".MARINE DRUGS 12.3(2014):1530-1544. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| CS5931, a Novel Poly（1171KB） | 限制开放 | ODC PDDL | 浏览 | |||
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