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Prenylated Indolediketopiperazine Peroxides and Related Homologues from the Marine Sediment- Derived Fungus Penicillium brefeldianum SD-273
An, Chun-Yan1,2; Li, Xiao-Ming1; Li, Chun-Shun1; Xu, Gang-Ming1; Wang, Bin-Gui1; Wang, BG (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China.
2014-02-01
发表期刊MARINE DRUGS
卷号12期号:2页码:746-756
文章类型Article
摘要Three new indolediketopiperazine peroxides, namely, 24-hydroxyverruculogen (1), 26-hydroxyverruculogen (2), and 13-O-prenyl-26-hydroxyverruculogen (3), along with four known homologues (4-7), were isolated and identified from the culture extract of the marine sediment-derived fungus Penicillium brefeldianum SD-273. Their structures were determined based on the extensive spectroscopic analysis and compound 1 was confirmed by X-ray crystallographic analysis. The absolute configuration of compounds 1-3 was determined using chiral HPLC analysis of their acidic hydrolysates. Each of the isolated compounds was evaluated for antibacterial and cytotoxic activity as well as brine shrimp (Artemia salina) lethality.
关键词Marine Sediment Penicillium Brefeldianum Sd-273 Indolediketopiperazine Brine Shrimp Lethality
学科领域Pharmacology & Pharmacy
DOI10.3390/md12020746
收录类别SCI
语种英语
WOS记录号WOS:000335745100008
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/24150
专题实验海洋生物学重点实验室
通讯作者Wang, BG (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China.
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位实验海洋生物学重点实验室
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GB/T 7714
An, Chun-Yan,Li, Xiao-Ming,Li, Chun-Shun,et al. Prenylated Indolediketopiperazine Peroxides and Related Homologues from the Marine Sediment- Derived Fungus Penicillium brefeldianum SD-273[J]. MARINE DRUGS,2014,12(2):746-756.
APA An, Chun-Yan,Li, Xiao-Ming,Li, Chun-Shun,Xu, Gang-Ming,Wang, Bin-Gui,&Wang, BG .(2014).Prenylated Indolediketopiperazine Peroxides and Related Homologues from the Marine Sediment- Derived Fungus Penicillium brefeldianum SD-273.MARINE DRUGS,12(2),746-756.
MLA An, Chun-Yan,et al."Prenylated Indolediketopiperazine Peroxides and Related Homologues from the Marine Sediment- Derived Fungus Penicillium brefeldianum SD-273".MARINE DRUGS 12.2(2014):746-756.
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