Oleanolic acid induces protective autophagy in cancer cells through the JNK and mTOR pathways

doi:10.3892/or.2014.3239

IOCAS-IR > 实验海洋生物学重点实验室

	Oleanolic acid induces protective autophagy in cancer cells through the JNK and mTOR pathways
	Liu, Jia 1,3; Zheng, Lanhong 2; Zhong, Jiateng 5; Wu, Ning 1; Liu, Ge 1,3; Lin, Xiukun 1,4; Zheng, LH (reprint author), Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, 7 Nanhai Rd, Qingdao 266071, Shandong, Peoples R China.
	2014-08-05
发表期刊	ONCOLOGY REPORTS
卷号	32 期号:2 页码:567-572
文章类型	Article
摘要	Autophagy is a biological process that eliminates damaged or excessive proteins and is utilized by various types of cells to maintain cellular homeostasis. Autophagy also occurs in cancer cells and exerts anti-survival or pro-survival effects depending on stimuli, nutrient and context. Oleanolic acid (OA), a widely spread natural compound, induces apoptosis in a range of cancer cells. However, some tumor cell lines are resistant to the pro-apoptotic effect of OA, and the mechanism remains unknown. In the present study, we found that OA induced autophagic event in cancer cells in a dose- and time-dependent manner, evidenced by an increased ratio between LC3-II and LC3-I and frequent granulation of LC3 proteins in OA-stimulated tumor cell lines. Inhibition of autophagy potentiated the pro-apoptotic activity of OA on cancer cells. Furthermore, the JNK and mTOR signaling pathways were found to be affected by OA treatment. Interfering with INK and mTOR abolished OA-induced autophagy and sensitized cancer cells to apoptosis. Collectively, we showed that OA was able to initiate protective autophagy, which compromised the antitumor activity of OA on cancer cells. Blocking autophagy may be a promising strategy to enhance the tumor suppressor activity of OA.
关键词	Oleanolic Acid Autophagy Cancer Mammalian Target Of Rapamycin C-jun N-terminal Kinase
学科领域	Oncology
DOI	10.3892/or.2014.3239
收录类别	SCI
语种	英语
WOS记录号	WOS:000338908700016
引用统计	被引频次：40[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/24138
专题	实验海洋生物学重点实验室
通讯作者	Zheng, LH (reprint author), Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, 7 Nanhai Rd, Qingdao 266071, Shandong, Peoples R China.
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Shandong, Peoples R China 2.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Shandong, Peoples R China 3.Univ Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 4.Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China 5.Jilin Univ, Norman Bethune Coll Med, Dept Pathophysiol, Changchun 130021, Jilin, Peoples R China
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Liu, Jia,Zheng, Lanhong,Zhong, Jiateng,et al. Oleanolic acid induces protective autophagy in cancer cells through the JNK and mTOR pathways[J]. ONCOLOGY REPORTS,2014,32(2):567-572.
APA	Liu, Jia.,Zheng, Lanhong.,Zhong, Jiateng.,Wu, Ning.,Liu, Ge.,...&Zheng, LH .(2014).Oleanolic acid induces protective autophagy in cancer cells through the JNK and mTOR pathways.ONCOLOGY REPORTS,32(2),567-572.
MLA	Liu, Jia,et al."Oleanolic acid induces protective autophagy in cancer cells through the JNK and mTOR pathways".ONCOLOGY REPORTS 32.2(2014):567-572.

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Oleanolic acid induc（926KB）			限制开放	ODC PDDL	浏览