Functional analysis on immune deficiency (IMD) homolog gene in Chinese shrimp Fenneropenaeus chinensis

doi:10.1007/s11033-013-2988-2

IOCAS-IR > 实验海洋生物学重点实验室

	Functional analysis on immune deficiency (IMD) homolog gene in Chinese shrimp Fenneropenaeus chinensis
	Feng, Ningning 1,2; Wang, Dongdong 1,2; Wen, Rong 1,2; Li, Fuhua 1; Li, FH (reprint author), Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Peoples R China.
	2014-03-01
发表期刊	MOLECULAR BIOLOGY REPORTS
卷号	41 期号:3 页码:1437-1444
文章类型	Article
摘要	IMD pathway is an important signaling pathway in regulating the innate immunity of invertebrate. IMD is regarded as a key adaptor to link the extracellular signals and intracellular signals. In the present study, a full-length cDNA encoding an IMD homolog (FcIMD) was isolated from Chinese shrimp Fenneropenaeus chinensis. It consists of 767 bp with a 483 bp open reading frame encoding 160 amino acids. A death domain was predicted which is crucial to the immune function of IMD. Tissue expression analysis showed that FcIMD mRNA had different expression level in different tissues. The transcriptional expression of FcIMD in shrimp was significantly induced at early stage (1 h) after stimulation by Vibrio or Micrococcus which suggested its important role in the immunity of shrimp to bacterium infection. The expressions of shrimp antimicrobial peptides (AMPs) were affected when FcIMD was silenced by dsRNA interference. Through analyzing the expression of FcRelish, FcDorsal and FcJNK in FcIMD silenced shrimp at 1 h post Vibrio injection, we deduced that IMD was involved in Relish regulated signaling pathway, not in Dorsal or JNK regulated signaling pathway.
关键词	Fcimd Innate Immunity Imd Pathway Amps
学科领域	Biochemistry & Molecular Biology
DOI	10.1007/s11033-013-2988-2
收录类别	SCI
语种	英语
WOS记录号	WOS:000332000400027
引用统计	被引频次：18[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/24116
专题	实验海洋生物学重点实验室
通讯作者	Li, FH (reprint author), Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Peoples R China.
作者单位	1.Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Feng, Ningning,Wang, Dongdong,Wen, Rong,et al. Functional analysis on immune deficiency (IMD) homolog gene in Chinese shrimp Fenneropenaeus chinensis[J]. MOLECULAR BIOLOGY REPORTS,2014,41(3):1437-1444.
APA	Feng, Ningning,Wang, Dongdong,Wen, Rong,Li, Fuhua,&Li, FH .(2014).Functional analysis on immune deficiency (IMD) homolog gene in Chinese shrimp Fenneropenaeus chinensis.MOLECULAR BIOLOGY REPORTS,41(3),1437-1444.
MLA	Feng, Ningning,et al."Functional analysis on immune deficiency (IMD) homolog gene in Chinese shrimp Fenneropenaeus chinensis".MOLECULAR BIOLOGY REPORTS 41.3(2014):1437-1444.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Functional analysis （739KB）			限制开放	ODC PDDL	浏览