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Cyclohexadepsipeptides of the Isaridin Class from the Marine-Derived Fungus Beauveria felina EN-135
Du, Feng-Yu1; Zhang, Peng1,2; Li, Xiao-Ming1; Li, Chun-Shun1; Cui, Chuan-Ming1; Wang, Bin-Gui1; Li, XM (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China.
2014-05-01
发表期刊JOURNAL OF NATURAL PRODUCTS
卷号77期号:5页码:1164-1169
文章类型Article
摘要Three new cyclohexadepsipeptides of the isaridin class including isaridin G (1), desmethylisaridin G (2), and desmethylisaridin C1 (3), along with three related known metabolites (4-6), were isolated and identified from the marine bryozoan-derived fungus Beauveria felina EN-135. The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis, and the structures and absolute configurations of compounds 1-3 were confirmed by single-crystal X-ray diffraction analysis. The crystal structures showed the presence of beta-turns for the Tyr(3)/N-Me-Val(4) and Phe(3)/N-Me-Val(4) amide bonds in compounds 2 and 3, respectively, in the cis conformations, which were opposite other reported isaridins. The conformations of the HMPA(1)-Pro(2) amide bond in compound 2 are different in the solution and in the crystal structures, which showed trans and cis geometries, respectively, while compounds 1 and 3 do not exhibit this phenomenon. Each of the isolated compounds was evaluated for antimicrobial activity and brine shrimp lethality. Compound 3 exhibited antibacterial activity against E. coli with an MIC value of 8 mu g/mL.
学科领域Plant Sciences ; Pharmacology & Pharmacy
DOI10.1021/np4011037
收录类别SCI ; IC
语种英语
WOS记录号WOS:000336510700011
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/24099
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Du, Feng-Yu,Zhang, Peng,Li, Xiao-Ming,et al. Cyclohexadepsipeptides of the Isaridin Class from the Marine-Derived Fungus Beauveria felina EN-135[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(5):1164-1169.
APA Du, Feng-Yu.,Zhang, Peng.,Li, Xiao-Ming.,Li, Chun-Shun.,Cui, Chuan-Ming.,...&Li, XM .(2014).Cyclohexadepsipeptides of the Isaridin Class from the Marine-Derived Fungus Beauveria felina EN-135.JOURNAL OF NATURAL PRODUCTS,77(5),1164-1169.
MLA Du, Feng-Yu,et al."Cyclohexadepsipeptides of the Isaridin Class from the Marine-Derived Fungus Beauveria felina EN-135".JOURNAL OF NATURAL PRODUCTS 77.5(2014):1164-1169.
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