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	CpG methylation of dmrt1 and cyp19a promoters in relation to their sexual dimorphic expression in the Japanese flounder Paralichthys olivaceus
	Wen, A. Y.1,2; You, F.1; Sun, P.1; Li, J.3; Xu, D. D.1; Wu, Z. H.1; Ma, D. Y.1; Zhang, P. J.1; You, F (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China.
	2014
发表期刊	JOURNAL OF FISH BIOLOGY
卷号	84期号:1页码:193-205
文章类型	Article
摘要	To better understand the effects of DNA methylation on the expression patterns of dmrt1 (Doublesex and Mab-3-related transcription factor 1) and cyp19a (Cytochrome P450 19a) in the Japanese flounder Paralichthys olivaceus, quantitative expressions, cellular distributions and cytosine-p-guanine (CpG) methylation patterns of these two genes in the gonads were analysed. The results showed that P. olivaceus dmrt1 expression was 70 times higher in the testis than in the ovary (P < 005). Its mRNA was detected clearly in spermatocytes and Sertoli cells of the testis, but weakly in the ovary. Paralichthys olivaceus cyp19a expression was 40 times higher in the ovary than in the testis (P < 001). Its mRNA was detected clearly in follicular cells of the ovary, but weakly in spermatocytes of the testis. The dmrt1 promoter CpGs were not methylated in the testis, whereas 5769% were methylated in the ovary. For the cyp19a promoter CpGs, 975% were methylated in the testis and 7333% were methylated in the ovary. These findings demonstrate that P. olivaceus dmrt1 and cyp19a are sex-related genes with sexual dimorphic expression, CpG methylation levels of the two genes are consistent with their expression quantities, and this epigenetic modification can influence the differential expression of genes in the gonads of P. olivaceus.
关键词	Dna Methylation Level Gonads Sex-related Gene
学科领域	Fisheries ; Marine & Freshwater Biology
DOI	10.1111/jfb.12277
收录类别	SCI
语种	英语
WOS记录号	WOS:000329367100013
引用统计	被引频次：71[WOS]   [WOS记录]     [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/24096
专题	实验海洋生物学重点实验室 海洋地质与环境重点实验室
通讯作者	You, F (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China.
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China 2.Univ Chinese Acad Sci, Coll Earth Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Marine Biol Technol Engn Res & Dev Ctr, Qingdao 266071, Shandong, Peoples R China
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Wen, A. Y.,You, F.,Sun, P.,et al. CpG methylation of dmrt1 and cyp19a promoters in relation to their sexual dimorphic expression in the Japanese flounder Paralichthys olivaceus[J]. JOURNAL OF FISH BIOLOGY,2014,84(1):193-205.
APA	Wen, A. Y..,You, F..,Sun, P..,Li, J..,Xu, D. D..,...&You, F .(2014).CpG methylation of dmrt1 and cyp19a promoters in relation to their sexual dimorphic expression in the Japanese flounder Paralichthys olivaceus.JOURNAL OF FISH BIOLOGY,84(1),193-205.
MLA	Wen, A. Y.,et al."CpG methylation of dmrt1 and cyp19a promoters in relation to their sexual dimorphic expression in the Japanese flounder Paralichthys olivaceus".JOURNAL OF FISH BIOLOGY 84.1(2014):193-205.

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