Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Co-Cultivation-A Powerful Emerging Tool for Enhancing the Chemical Diversity of Microorganisms | |
Marmann, Andreas1; Aly, Amal H.1; Lin, Wenhan2; Wang, Bingui3 ; Proksch, Peter1; Proksch, P (reprint author), Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, Univ Str 1,Bldg 26-23, D-40225 Dusseldorf, Germany.
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| 2014-02-01 | |
| 发表期刊 | MARINE DRUGS
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| 卷号 | 12期号:2页码:1043-1065 |
| 文章类型 | Review |
| 摘要 | Marine-derived bacteria and fungi are promising sources of novel bioactive compounds that are important for drug discovery programs. However, as encountered in terrestrial microorganisms there is a high rate of redundancy that results in the frequent re-discovery of known compounds. Apparently only a part of the biosynthetic genes that are harbored by fungi and bacteria are transcribed under routine laboratory conditions which involve cultivation of axenic microbial strains. Many biosynthetic genes remain silent and are not expressed in vitro thereby seriously limiting the chemical diversity of microbial compounds that can be obtained through fermentation. In contrast to this, co-cultivation (also called mixed fermentation) of two or more different microorganisms tries to mimic the ecological situation where microorganisms always co-exist within complex microbial communities. The competition or antagonism experienced during co-cultivation is shown to lead to a significantly enhanced production of constitutively present compounds and/or to an accumulation of cryptic compounds that are not detected in axenic cultures of the producing strain. This review highlights the power of co-cultivation for increasing the chemical diversity of bacteria and fungi drawing on published studies from the marine and from the terrestrial habitat alike. |
| 关键词 | Marine-derived Microorganisms Co-cultivation Mixed Fermentation Silent Genes Natural Products |
| 学科领域 | Pharmacology & Pharmacy |
| DOI | 10.3390/md12021043 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000335745100030 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/24090 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Proksch, P (reprint author), Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, Univ Str 1,Bldg 26-23, D-40225 Dusseldorf, Germany. |
| 作者单位 | 1.Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, D-40225 Dusseldorf, Germany 2.Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Marmann, Andreas,Aly, Amal H.,Lin, Wenhan,et al. Co-Cultivation-A Powerful Emerging Tool for Enhancing the Chemical Diversity of Microorganisms[J]. MARINE DRUGS,2014,12(2):1043-1065. |
| APA | Marmann, Andreas,Aly, Amal H.,Lin, Wenhan,Wang, Bingui,Proksch, Peter,&Proksch, P .(2014).Co-Cultivation-A Powerful Emerging Tool for Enhancing the Chemical Diversity of Microorganisms.MARINE DRUGS,12(2),1043-1065. |
| MLA | Marmann, Andreas,et al."Co-Cultivation-A Powerful Emerging Tool for Enhancing the Chemical Diversity of Microorganisms".MARINE DRUGS 12.2(2014):1043-1065. |
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