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题名: Brocazines A-F, Cytotoxic Bisthiodiketopiperazine Derivatives from Penicillium brocae MA-231, an Endophytic Fungus Derived from the Marine Mangrove Plant Avicennia marina
作者: Meng LingHong(孟令红)1,2; Li, Xiao-Ming1; Lv, Cui-Ting3; Huang, Cai-Guo3; Wang, BinGui(王斌贵)1
刊名: JOURNAL OF NATURAL PRODUCTS
出版日期: 2014-08-01
卷号: 77, 期号:8, 页码:1921-1927
学科分类: Plant Sciences; Pharmacology & Pharmacy
DOI: 10.1021/np500382k
通讯作者: Huang, CG (reprint author), Second Mil Med Univ, Dept Biochem & Mol Biol, Xiangyin Rd 800, Shanghai 200433, Peoples R China.
文章类型: Article
英文摘要: Six new disulfide-bridged diketopiperazine derivatives, brocazines A-F (1-6), along with one known analogue (7), were isolated and identified from the cytotoxic extract of Penicillium brocae MA-231, a fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of these compounds were established on the basis of detailed interpretation of NMR and mass spectroscopic data. X-ray crystallographic analysis confirmed the structure of 1 and established the structure and absolute configuration of 5, while the absolute configurations for compounds 1, 4, and 6 were deduced by comparison of the CD data with those of S. Compounds 1, 2, 5, and 6 showed cytotoxic activities against several tumor cell lines.
收录类别: SCI ; IC
语种: 英语
WOS记录号: WOS:000340861800021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.qdio.ac.cn/handle/337002/24080
Appears in Collections:实验海洋生物学重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Second Mil Med Univ, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China
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文件名: Brocazines A-F, Cytotoxic Bisthiodiketopiperazine Derivatives from Penicillium brocae MA-231, an Endophytic Fungus Derived from the Marine Mangrove Plant Avicennia marina.pdf
格式: Adobe PDF
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