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Brocazines A-F, Cytotoxic Bisthiodiketopiperazine Derivatives from Penicillium brocae MA-231, an Endophytic Fungus Derived from the Marine Mangrove Plant Avicennia marina
Meng, Ling-Hong1,2; Li, Xiao-Ming1; Lv, Cui-Ting3; Huang, Cai-Guo3; Wang, Bin-Gui1; Huang, CG (reprint author), Second Mil Med Univ, Dept Biochem & Mol Biol, Xiangyin Rd 800, Shanghai 200433, Peoples R China.
2014-08-01
发表期刊JOURNAL OF NATURAL PRODUCTS
卷号77期号:8页码:1921-1927
文章类型Article
摘要Six new disulfide-bridged diketopiperazine derivatives, brocazines A-F (1-6), along with one known analogue (7), were isolated and identified from the cytotoxic extract of Penicillium brocae MA-231, a fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of these compounds were established on the basis of detailed interpretation of NMR and mass spectroscopic data. X-ray crystallographic analysis confirmed the structure of 1 and established the structure and absolute configuration of 5, while the absolute configurations for compounds 1, 4, and 6 were deduced by comparison of the CD data with those of S. Compounds 1, 2, 5, and 6 showed cytotoxic activities against several tumor cell lines.
学科领域Plant Sciences ; Pharmacology & Pharmacy
DOI10.1021/np500382k
收录类别SCI ; IC
语种英语
WOS记录号WOS:000340861800021
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/24080
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Second Mil Med Univ, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China
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GB/T 7714
Meng, Ling-Hong,Li, Xiao-Ming,Lv, Cui-Ting,et al. Brocazines A-F, Cytotoxic Bisthiodiketopiperazine Derivatives from Penicillium brocae MA-231, an Endophytic Fungus Derived from the Marine Mangrove Plant Avicennia marina[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(8):1921-1927.
APA Meng, Ling-Hong,Li, Xiao-Ming,Lv, Cui-Ting,Huang, Cai-Guo,Wang, Bin-Gui,&Huang, CG .(2014).Brocazines A-F, Cytotoxic Bisthiodiketopiperazine Derivatives from Penicillium brocae MA-231, an Endophytic Fungus Derived from the Marine Mangrove Plant Avicennia marina.JOURNAL OF NATURAL PRODUCTS,77(8),1921-1927.
MLA Meng, Ling-Hong,et al."Brocazines A-F, Cytotoxic Bisthiodiketopiperazine Derivatives from Penicillium brocae MA-231, an Endophytic Fungus Derived from the Marine Mangrove Plant Avicennia marina".JOURNAL OF NATURAL PRODUCTS 77.8(2014):1921-1927.
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