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Allyl Isothiocyanate Ameliorates Angiogenesis and Inflammation in Dextran Sulfate Sodium-Induced Acute Colitis
Davaatseren, Munkhtugs1,2; Hwang, Jin-Taek1; Park, Jae Ho1; Kim, Myung-Sunny1; Wang, Shuaiyu3; Sung, Mi Jeong1; Sung, MJ (reprint author), Korea Food Res Inst, Res Div Emerging Innovat Technol, Songnam, Keongki, South Korea.
2014-07-22
发表期刊PLOS ONE
卷号9期号:7页码:e102975
文章类型Article
摘要Allyl isothiocyanate (AITC) is a phytochemical found in cruciferous vegetables that has known chemopreventive and chemotherapeutic activities. Thus far, the antiangiogenic activity of AITC has not been reported in in vivo studies. Herein, we investigated the effect of AITC on angiogenesis and inflammation in a mouse model of colitis. Experimental colitis was induced in mice by administering 3% dextran sulfate sodium via drinking water. To monitor the activity of AITC in this model, we measured body weight, disease activity indices, histopathological scores, microvascular density, myeloperoxidase activity, F4/80 staining, inducible nitric oxide synthase (iNOS) expression, cyclooxygenase-2 (COX-2) expression, and vascular endothelial growth factor (VEGF)-A/VEGF receptor 2 (VEGFR2) expression in the mice. We found that AITC-treated mice showed less weight loss, fewer clinical signs of colitis, and longer colons than vehicle-treated mice. AITC treatment also significantly lessened the disruption of colonic architecture that is normally associated with colitis and repressed the microvascularization response. Further, AITC treatment reduced both leukocyte recruitment and macrophage infiltration into the inflamed colon, and the mechanism these activities involved repressing iNOS and COX-2 expression. Finally, AITC attenuated the expression of VEGF-A and VEGFR2. Thus, AITC may have potential application in treating conditions marked by inflammatory-driven angiogenesis and mucosal inflammation.
学科领域Science & Technology - Other Topics
DOI10.1371/journal.pone.0102975
收录类别SCI
语种英语
WOS记录号WOS:000339551100073
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/24068
专题实验海洋生物学重点实验室
通讯作者Sung, MJ (reprint author), Korea Food Res Inst, Res Div Emerging Innovat Technol, Songnam, Keongki, South Korea.
作者单位1.Korea Food Res Inst, Res Div Emerging Innovat Technol, Songnam, Keongki, South Korea
2.Konkuk Univ, Dept Bioresources & Food Sci, Seoul, South Korea
3.Chinese Acad Sci, Inst Oceanol, Qingdao, Shandong, Peoples R China
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Davaatseren, Munkhtugs,Hwang, Jin-Taek,Park, Jae Ho,et al. Allyl Isothiocyanate Ameliorates Angiogenesis and Inflammation in Dextran Sulfate Sodium-Induced Acute Colitis[J]. PLOS ONE,2014,9(7):e102975.
APA Davaatseren, Munkhtugs.,Hwang, Jin-Taek.,Park, Jae Ho.,Kim, Myung-Sunny.,Wang, Shuaiyu.,...&Sung, MJ .(2014).Allyl Isothiocyanate Ameliorates Angiogenesis and Inflammation in Dextran Sulfate Sodium-Induced Acute Colitis.PLOS ONE,9(7),e102975.
MLA Davaatseren, Munkhtugs,et al."Allyl Isothiocyanate Ameliorates Angiogenesis and Inflammation in Dextran Sulfate Sodium-Induced Acute Colitis".PLOS ONE 9.7(2014):e102975.
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