Synthesis and Bioactivity of Novel Benzisothiazolone Derivatives as Potential Microbiocides

doi:10.1002/jhet.65

	Synthesis and Bioactivity of Novel Benzisothiazolone Derivatives as Potential Microbiocides
	Xu, Fengling 2,3; Lin, Qiang 1; Hou, Baorong 2
	2009-03-01
发表期刊	JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN	0022-152X
卷号	46 期号:2 页码:320-323
文章类型	Article
摘要	Novel microbiocides 2-(hydroxymethyl)benzo[d)isothiazol-3(2H)-one (7) and (3-oxobenzo[d]isothiazol-2(3H)-yl)methyl benzencarboxylates (11a-c) were synthesized in good yields, and their structures were characterized by means of (1)H NMR, MS, and elemental analysis. The new compounds were tested preliminarily in laboratory assays against the aquicolous bacteria including Escherichia coli, Staphyloccus aurueus, Vibrio alginolyticus, Aeromonas hydrophila, and Bacillus subtilis. The results show all the synthesized compounds have good antimicrobial activity. The antimicrobial activity of all the tested compounds against all test bacteria is >96.6% at the concentration of 10(-2) mg mL(-1). These compounds can be further developed for effective microbiocides in the future.; Novel microbiocides 2-(hydroxymethyl)benzo[d)isothiazol-3(2H)-one (7) and (3-oxobenzo[d]isothiazol-2(3H)-yl)methyl benzencarboxylates (11a-c) were synthesized in good yields, and their structures were characterized by means of H-1 NMR, MS, and elemental analysis. The new compounds were tested preliminarily in laboratory assays against the aquicolous bacteria including Escherichia coli, Staphyloccus aurueus, Vibrio alginolyticus, Aeromonas hydrophila, and Bacillus subtilis. The results show all the synthesized compounds have good antimicrobial activity. The antimicrobial activity of all the tested compounds against all test bacteria is >96.6% at the concentration of 10(-2) mg mL(-1). These compounds can be further developed for effective microbiocides in the future.
关键词	2-(4-substituted Phenyl)-3(2h)-isothiazolones Antibacterial Activity
学科领域	Chemistry, Organic
DOI	10.1002/jhet.65
URL	查看原文
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000265992700033
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/2274
专题	海洋环境腐蚀与生物污损重点实验室
作者单位	1.Hainan Univ, Key Lab Trop Biol Resources, Haikou 570228, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Key Lab Corros Sci Shandong, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Xu, Fengling,Lin, Qiang,Hou, Baorong. Synthesis and Bioactivity of Novel Benzisothiazolone Derivatives as Potential Microbiocides[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY,2009,46(2):320-323.
APA	Xu, Fengling,Lin, Qiang,&Hou, Baorong.(2009).Synthesis and Bioactivity of Novel Benzisothiazolone Derivatives as Potential Microbiocides.JOURNAL OF HETEROCYCLIC CHEMISTRY,46(2),320-323.
MLA	Xu, Fengling,et al."Synthesis and Bioactivity of Novel Benzisothiazolone Derivatives as Potential Microbiocides".JOURNAL OF HETEROCYCLIC CHEMISTRY 46.2(2009):320-323.

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